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Case Reports in Veterinary Medicine
Volume 2013, Article ID 703732, 4 pages
http://dx.doi.org/10.1155/2013/703732
Case Report

Aniridia in Two Related Tennessee Walking Horses

1Large Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996, USA
2Small Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996, USA
3Diagnostic and Biomedical Sciences, University of Tennessee, College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996, USA

Received 26 April 2013; Accepted 23 May 2013

Academic Editors: L. Espino López, S. Hecht, F. Mutinelli, and S. Stuen

Copyright © 2013 Karen A. McCormick et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Z. Saunders and M. G. Fincher, “Hereditary multiple eye defects in grade Jersey calves,” The Cornell Veterinarian, vol. 41, no. 4, pp. 351–366, 1951. View at Google Scholar · View at Scopus
  2. T. Glaser, J. Lane, and D. Housman, “A mouse model of the aniridia-Wilms tumor deletion syndrome,” Science, vol. 250, no. 4982, pp. 823–827, 1990. View at Google Scholar · View at Scopus
  3. T. Glaser, D. S. Walton, and R. L. Maas, “Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene,” Nature Genetics, vol. 2, no. 3, pp. 232–239, 1992. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Kokotas and M. B. Petersen, “Clinical and molecular aspects of aniridia,” Clinical Genetics, vol. 77, no. 5, pp. 409–420, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Lee, R. Khan, and M. O'keefe, “Aniridia: current pathology and management,” Acta Ophthalmologica, vol. 86, no. 7, pp. 708–715, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Eriksson, “Hereditary aniridia with secondary cataract in horses,” Nordisk Veterinaermedicin, vol. 7, pp. 773–779, 1955. View at Google Scholar
  7. J. R. Joyce, J. E. Martin, R. W. Storts, and L. Skow, “Iridial hypoplasia (aniridia) accompanied by limbic dermoids and cataracts in a group of related quarterhorses,” Equine Veterinary Journal, vol. 22, no. 10, pp. 26–28, 1990. View at Google Scholar · View at Scopus
  8. N. Håkanson, “Irishypoplasi hos häst,” Svensk Veterinärtidning, vol. 45, pp. 99–103, 1993. View at Google Scholar
  9. J. Joyce, “Aniridia in a Quarter horse,” Equine Veterinary Journal, vol. 15, no. 2, pp. 21–22, 1983. View at Google Scholar
  10. Y. Ueda, “Aniridia in a thoroughbred horse,” Equine Veterinary Journal, vol. 22, no. 10, p. 29, 1990. View at Google Scholar · View at Scopus
  11. N. L. Irby and G. D. Aguirre, “Congenital aniridia in a pony,” Journal of the American Veterinary Medical Association, vol. 186, no. 3, pp. 281–283, 1985. View at Google Scholar · View at Scopus
  12. C. S. Cook, “Ocular embryology and congenital malformations,” in Veterinary Ophthalmology, K. N. Gelatt, Ed., pp. 3–36, Blackwell Publishing, Ames, Iowa, USA, 4th edition, 2007. View at Google Scholar
  13. G. R. Beauchamp and D. M. Meisler, “An alternative hypothesis for iris maldevelopment (aniridia),” Journal of Pediatric Ophthalmology and Strabismus, vol. 23, no. 6, pp. 281–283, 1986. View at Google Scholar · View at Scopus
  14. A. Cvekl, C. M. Sax, E. H. Bresnick, and J. Piatigorsky, “A complex array of positive and negative elements regulates the chicken αA-crystallin gene: Involvement of Pax-6, USF, CREB and/or CREM, and AP-1 proteins,” Molecular and Cellular Biology, vol. 14, no. 11, pp. 7363–7376, 1994. View at Google Scholar · View at Scopus
  15. D. C. Baulmann, A. Ohlmann, C. Flügel-Koch, S. Goswami, A. Cvekl, and E. R. Tamm, “Pax6 heterozygous eyes show defects in chamber angle differentiation that are associated with a wide spectrum of other anterior eye segment abnormalities,” Mechanisms of Development, vol. 118, no. 1-2, pp. 3–17, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. D. T. Ramsey, S. L. Ewart, J. A. Render, C. S. Cook, and C. A. Latimer, “Congenital ocular abnormalities of Rocky Mountain Horses,” Veterinary Ophthalmology, vol. 2, no. 1, pp. 47–59, 1999. View at Google Scholar · View at Scopus
  17. S. L. Ewart, D. T. Ramsey, J. Xu, and D. Meyers, “The horse homolog of congenital aniridia conforms to codominant inheritance,” Journal of Heredity, vol. 91, no. 2, pp. 93–98, 2000. View at Google Scholar · View at Scopus
  18. J. Davis and J. Piatigorsky, “Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation,” Investigative Ophthalmology & Visual Science, vol. 52, no. 7, pp. 4158–4168, 2011. View at Google Scholar · View at Scopus
  19. A. Cvekl, Y. Yang, B. K. Chauhan, and K. Cveklova, “Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens,” International Journal of Developmental Biology, vol. 48, no. 8-9, pp. 829–844, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Tremblay, S. K. Gupta, I. de Becker, D. L. Guernsey, and P. E. Neumann, “Effects of PAX6 mutations on retinal function: an electroretinographic study,” American Journal of Ophthalmology, vol. 126, no. 2, pp. 211–218, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. W. H. Spencer and L. E. Zimmerman, “Conjunctiva,” in Ophthalmic Pathology: An Atlas and Textbook, W. H. Spencer, Ed., vol. 1, pp. 109–228, WB Saunders, Philadelphia, Pa, USA, 3rd edition, 1985. View at Google Scholar