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Case Reports in Veterinary Medicine
Volume 2013, Article ID 907276, 4 pages
http://dx.doi.org/10.1155/2013/907276
Case Report

Successful Long-Term Use of Itraconazole for the Treatment of Aspergillus Diskospondylitis in a Dog

1Texas A&M University College of Veterinary Medicine, 422 Raymond Stotzer Parkway, College Station, TX 77843, USA
2Washington State University College of Veterinary Medicine, P.O. Box 647010, Pullman, WA 99164, USA

Received 1 December 2012; Accepted 30 December 2012

Academic Editors: F. Mutinelli, J. Orós, L. G. Papazoglou, and P. Roccabianca

Copyright © 2013 Emiko Van Wie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A 5-year-old spayed female German shepherd dog was admitted with a history of generalized stiffness. Neurologic examination revealed mild paraparesis with multifocal spinal pain. Spinal radiographs and magnetic resonance imaging revealed diskospondylitis at L6-7 and multiple sites throughout the thoracolumbar spine. Biopsy of the intervertebral disk at L6-7 revealed a positive culture for Aspergillus species, and the dog was placed on itraconazole indefinitely. Clinical signs were significantly improved after two weeks of itraconazole. The dog was reevaluated 8 years later for unrelated reasons. No spinal pain was detected. Spinal radiographs revealed a fused L6-7 disk space and collapsed and sclerotic disk spaces at multiple sites. Itraconazole was tolerated by the dog with normal yearly liver enzyme values. To our knowledge, this is the first reported case of successful long-term use of itraconazole for the treatment of Aspergillus diskospondylitis in a dog.