Elevated Testosterone and Progestin Concentrations in a Spayed Female Rabbit with an Adrenal Cortical Adenoma

Figure 2

Adrenal gland from a rabbit. (a) The adrenal medulla is replaced by a well-demarcated mass of neoplastic cells (asterisk), which compresses the overlying adrenal cortex. There is also extracapsular adrenal cortical hyperplasia (arrow). Hematoxylin and eosin (H&E) stain. Bar = 200 μm. (b) The neoplastic cells are round to polygonal and occasionally form cords or nests, which are separated by vascular spaces. Occasionally the cytoplasm is vacuolated. H&E stain. Bar = 10 μm. (c) Compressed normal adrenal medulla with brown cytoplasmic granules. Churukian-Schenk stain. Bar = 10 μm. (d) The neoplastic cells do not contain brown cytoplasmic granules. Churukian-Schenk stain. Bar = 10 μm.

(a)

(b)

(c)

(d)