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Case Reports in Veterinary Medicine
Volume 2014, Article ID 519197, 4 pages
Case Report

Canine Oral Eosinophilic Granuloma Treated with Electrochemotherapy

1Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Avenida Chorroarín 280, C1427CWO Ciudad de Buenos Aires, Argentina
2Instituto Tecnológico de Buenos Aires, Avenida Eduardo Madero 399, C1106ACD Ciudad de Buenos Aires, Argentina
3Laboratorio de Sistemas Complejos, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Guiraldes 2160, Pabellon I, C1428EGA Ciudad de Buenos Aires, Argentina

Received 24 June 2014; Accepted 7 October 2014; Published 16 October 2014

Academic Editor: Isabel Pires

Copyright © 2014 Matías Nicolás Tellado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A case of a canine oral eosinophilic granuloma in a 14-year-old female crossbred is described. The dog was presented with a history of ptyalism, halitosis, local pain, decreased appetite, and blood staining noted on food and water bowls. Clinical, hematologic, and biochemical examinations, abdominal ultrasonography, and 3-view chest radiographs were performed, and no metastases were found. Histopathologic examination of two 6 mm punch biopsies from the oral lesion revealed the presence of eosinophilic granulomatous lesions in the submucosa. After treatment with corticosteroids and wide spectrum antibiotics no significant changes in clinical signs and lesion size were observed. Electrochemotherapy (ECT), a novel tumor treatment routinely used for cutaneous and subcutaneous tumors in human patients in the European Union since 2006, was used to treat the eosinophilic granuloma. The procedure was performed under general anesthesia, followed by intravenous administration of bleomycin. Six weeks after treatment a complete response with disappearance of the mass and improvement of clinical signs were observed.