Figure 2: Values of liver enzymes over time. Clinical chemistry indicated that liver enzymes (AST, ALT, and ALP) were within normal limits during the entire study except on day 58 when AST and ALT were temporarily elevated and over the upper limit (AST was 157 IU/L with a REF range of 15-66 IU/L; ALT was 161 IU/L with a REF range of 12-118 IU/L). All three liver enzymes returned to normal range by day 68.