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Canadian Respiratory Journal
Volume 3, Issue 6, Pages 368-369
http://dx.doi.org/10.1155/1996/306724
Mechanical Ventilation Symposium

High Frequency Oscillatory Ventilation

AC Bryan and D Bohn

Pediatric Intensive Care Unit, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

High frequency oscillatory (HFO) ventilation using low tidal volume and peak airway pressures is extremely efficient at eliminating carbon dioxide and raising pH in the newborn infant with acute respiratory failure. Improvement in oxygenation requires a strategy of sustained or repetitive inflations to 25 to 30 cm H2O in order to place the lung on the deflation limb of the pressure-volume curve. This strategy has also been shown to decrease the amount of secondary lung injury in animal models. Experience of the use of HFO ventilation as a rescue therapy as well as several published controlled trials have shown improved outcomes and a decrease in the use of extracorporeal membrane oxygenation when it has been used in newborns.