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Canadian Respiratory Journal
Volume 10 (2003), Issue 3, Pages 143-144
Case Report

Primary Chemoradiation as Definitive Treatment for Unresectable Cancer of the Trachea

Gregory MM Videtic,1 Carolyn Campbell,2 and Mark D Vincent3

1Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
2Department of Medical Oncology, Grand River Cancer Centre, Kitchener, Ontario, Canada
3Department of Medical Oncology, London Regional Cancer Centre, London, Ontario, Canada

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 64-year-old man was diagnosed with unresectable cancer of the trachea. He was treated definitively with a novel chemoradiation regimen. Cisplatin-based chemotherapy (ChT) was given for two cycles as induction, followed by concurrent administration of this ChT with external beam radiotherapy (RT) (total dose 60 Gy). An unexpected partial tumour response was noted after the induction of ChT alone. Six weeks after finishing ChT/RT, complete response of the lesion was noted on computed tomography imaging. Two years later, the patient was free of disease. Primary chemoradiation appears to be effective in managing locally advanced tracheal cancer.