Canadian Respiratory Journal

Canadian Respiratory Journal / 2004 / Article

Open Access

Volume 11 |Article ID 389625 | https://doi.org/10.1155/2004/389625

JF Lewis, "Surfactant — Where Are We in 2003?", Canadian Respiratory Journal, vol. 11, Article ID 389625, 3 pages, 2004. https://doi.org/10.1155/2004/389625

Surfactant — Where Are We in 2003?

Abstract

Surfactant research has progressed over the past several years to the extent that exogenous surfactant administration in patients with the acute respiratory distress syndrome (ARDS) is now being evaluated. Unfortunately, clinical responses have been variable, and we now need to take a look at how surfactant is altered in this disease so that more effective treatment strategies can be developed. This review briefly discusses the biophysical and host defense properties of surfactant, the impact of mechanical ventilation (MV) on the endogenous surfactant system and the most recent clinical data involving exogenous surfactant administration in patients with ARDS. Discussions regarding future directions of surfactant research both in ARDS and diseases other than acute lung injury are included.

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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