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Canadian Respiratory Journal
Volume 13, Issue 6, Pages 327-335

Mucin Overproduction in Chronic Inflammatory Lung Disease

Hans-Peter Hauber,1,2 Susan C Foley,1 and Qutayba Hamid1

1Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada
2Department of Medicine, Research Center Borstel, Borstel, Germany

Copyright © 2006 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by neutrophil elastase, bacteria, cytokines, growth factors, smoke and cystic fibrosis transmembrane conductance regulator malfunction are also discussed.