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Canadian Respiratory Journal
Volume 15 (2008), Issue 2, Pages 91-98
http://dx.doi.org/10.1155/2008/416095
Review

The Link between Allergic Rhinitis and Asthma: A Role for Antileukotrienes?

H Kim,1,2 J Bouchard,3 and PM Renzix4

1McMaster University, Hamilton, Canada
2University of Western Ontario, London, Ontario, Canada
3St Joseph’s Hospital, La Malbaie, Canada
4University of Montreal, Montreal, Quebec, Canada

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Allergic rhinitis and asthma are both chronic heterogeneous disorders, with an overlapping epidemiology of prevalence, health care costs and social costs in quality of life. Both are inflammatory disorders with a similar pathophysiology, and both share some treatment approaches. However, each disorder has an array of treatments used separately in controlling these atopic disorders, from inhaled corticosteroids, beta2-agonists and antihistamines to newer monoclonal antibody-based treatments. The present article reviews the shared components of allergic rhinitis and asthma, and examines recent evidence supporting antileukotrienes as effective agents in reducing the symptoms of both diseases.