Canadian Respiratory Journal

Canadian Respiratory Journal / 2012 / Article

Clinico-Pathologic Conferences | Open Access

Volume 19 |Article ID 734985 | 3 pages | https://doi.org/10.1155/2012/734985

Birt-Hogg-Dubé Syndrome: Report of a New Mutation

Abstract

Birt-Hogg-Dubé syndrome is an autosomal dominant genodermatosis caused by germline mutations in the folliculin gene and characterized by facial papules, pulmonary cysts, kidney tumours and recurrent pneumothoraces. Several distinct mutations in the folliculin gene resulting in a truncated protein have been described. The present report describes a new mutation, which has not been reported in individuals with Birt-Hogg-Dubé syndrome but is of a type predicted to cause disease.

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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