Outcomes and Predictors of Mortality for Patients with Acute Leukemia Admitted to the Intensive Care Unit
Table 2
Patient characteristics and outcomes ().
Characteristics at admission
Age, years
54 (15)
Female
76 (50)
APACHE II score
27 (22–33)
SOFA score
10 (8–13)
MODS
7 (6–10)
Neutropenia (neutrophils < 2.0 × 109/L)
84 (74)
Thrombocytopenia (platelets < 50 × 109/L)
126 (86)
Admission diagnosis
Sepsis
74 (49)
Respiratory
46 (31)
Cardiovascular failure
15 (10)
Gastrointestinal bleed
3 (2)
Neurological dysfunction
8 (5)
Other
5 (3)
Morbidity in ICU
Sepsis
128 (85)
Septic shock
87 (58)
Acute respiratory distress syndrome
56 (37)
Stroke
8 (5)
Treatments in ICU
Mechanical ventilation
94 (62)
NIV alone
11 (7)
NIV followed by intubation
15 (10)
Invasive alone
67 (44)
Total invasive ventilation
82 (54)
Total NIV
26 (17)
High frequency oscillation
12 (8)
Tracheostomy
8 (5)
Renal replacement therapy
23 (15)
Duration of renal replacement therapy (days)
4 (2–6)
Insulin infusion
50 (33)
Infections identified in ICU
Microbiologic pathogen identification
38 (25)
Bacterial
27 (18)
Viral
8 (5)
Fungal
7 (5)
Medications administered in ICU
Antibiotics
144 (95)
Antifungals
105 (70)
Chemotherapy
41 (27)
Sedatives/opioids
104 (69)
Infusion +/− boluses
68 (45)
Intermittent alone
36 (24)
Vasopressors
96 (64)
Neuromuscular blockers
26 (17)
Steroids
47 (31)
Antipsychotics
24 (16)
Outcomes
ICU stay, days
4 (2–8)
ICU survival
94 (62)
30-day survival
74 (49)
90-day survival
60 (40)
180-day survival
51 (34)
365-day survival
37 (25)
Data presented as (%) for categorical variables and mean (SD) or median (IQR) for continuous measures. Total number of bacterial, viral, and fungal infections is >38 as some patients had more than 1 pathogen identified. APACHE = acute physiology and chronic health evaluation score, MODS = multiple organ dysfunction score, SOFA = sequential organ failure assessment score, and NIV = noninvasive ventilation.