Identification of Susceptibility Genes of Adult Asthma in French Canadian Women
Table 1
Clinical characteristics of women.
Characteristics
Pooled GWAS
Individual genotyping
SLSJ asthma family collection
Cases ()
Controls ()
values
Cases ()
Controls ()
values
Cases ()
Controls ()
values
Age (years)
34.0 ± 13.9
35.2 ± 14.3
0.456
35.5 ± 14.8
36.0 ± 14.8
0.691
30.6 ± 17.8
40.6 ± 19.4
<0.0001
BMI (kg/m2)
25.3 ± 4.8
24.4 ± 4.1
0.066
25.9 ± 5.4
24.5 ± 4.5
0.001
24.5 ± 6.8
24.4 ± 6.0
0.887
FEV1 (% predicted)
95.1 ± 16.5
105.6 ± 11.7
<0.0001
94.4 ± 17.2
106.4 ± 12.2
<0.0001
92.5 ± 16.3
100.8 ± 14.2
<0.0001
FVC (% predicted)
107.5 ± 14.6
111.0 ± 12.9
0.021
106.5 ± 15.3
111.6 ± 13.4
<0.0001
99.6 ± 15.9
105.4 ± 15.9
0.001
AHR (positive : negative : NA)
189 : 33 : 18
11 : 109 : 0
<0.0001
258 : 55 : 36
25 : 233 : 3
<0.0001
108 : 29 : 96
18 : 42 : 60
<0.0001
Blood IgE (UI/mL)
321.7 ± 935.8
133.3 ± 252.1
<0.0001
279.3 ± 808.9
87.0 ± 190.6
<0.0001
606.7 ± 1089.9
231.5 ± 375.8
<0.0001
Blood eosinophils (%)
3.6 ± 2.6
2.4 ± 1.6
<0.0001
3.4 ± 2.5
2.2 ± 1.6
<0.0001
3.8 ± 2.7
2.7 ± 1.7
<0.0001
Atopy (positive : negative : NA)
240 : 0 : 0
120 : 0 : 0
<0.0001
299 : 46 : 4
154 : 107 : 0
<0.0001
221 : 0 : 12
111 : 0 : 9
<0.0001
Smoking status () [%]
Nonsmoker
166 [69.2]
85 [70.8]
0.001
225 [64.5]
190 [72.8]
0.002
155 [66.5]
54 [45.0]
0.001
Ex-smoker
69 [28.7]
23 [19.2]
110 [31.5]
52 [19.9]
37 [15.9]
33 [27.5]
Smoker
5 [2.1]
12 [10.0]
14 [4.0]
19 [7.3]
37 [15.9]
29 [24.2]
BMI, body mass index; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; AHR, airway hyperresponsiveness, defined as provocative concentration of methacholine inducing a 20% fall in FEV1 (PC20) <8 mg/mL; and IgE, immunoglobulin E. Continuous variables are expressed as mean ± SD. values were calculated using -test or chi-square tests as appropriate.
