Canadian Respiratory Journal

Review Article

Update on Nonsurgical Lung Volume Reduction Procedures

Table 2

Characteristics and outcomes of the larger published studies on endoscopic LVR for advanced emphysema (references [6–24]).


	Author, year	Study design	Patient population	Time point	ΔFEV₁	Δ6-MWD	ΔSGRQ (units)

Valves	Wan et al. 2006 [6]	Prospective multicenter registry		90 days	11 ± 3%	37 ± 90 m	—
	Sciurba et al. 2010 [7]	RCT	Treatment group ()	6 months	4%	9 m	−3
			Complete fissure ()		16%	8 m	—
			High heterogeneity ()		11%	12 m	—
	Sterman et al. 2010 [8]	Multicenter prospective cohort study		12 months	−2 ± 12%	14 ± 104 m	−8.2 ± 16
	Herth et al. 2012 [9]	RCT	Treatment group ()	6 months	7 ± 20%	15 ± 91 m	−5 ± 14
	Herth et al. 2012 [9]	RCT	Complete fissure, lobar occlusion ()	6 months	26 ± 24%	22 ± 38%	−10 ± 15
	Eberhardt et al. 2012 [10]	Prospective, randomized, noncontrolled	Complete unilateral occlusion ()	3 months	21 ± 11%	49 ± 53 m	−12 ± 11
	Eberhardt et al. 2012 [10]	Prospective, randomized, noncontrolled	Partial bilateral occlusion ()	3 months	−3 ± 15%	−52 ± 81 m	2 ± 9
	Ninane et al. 2012 [11]	RCT	Partial occlusion ()	3 months	−90 mL	7 m	−4
	Herth et al. 2013 [12]	Prospective, noncontrolled	CV negative ()	1 month	16 ± 22%	24 ± 57 m	−10 ± 13
	Herth et al. 2013 [12]	Prospective, noncontrolled	CV positive ()	1 month	1 ± 15%	10 ± 57 m	−5 ± 15
	Wood et al. 2014 [13]	RCT	Treatment group ()	6 months	−2 ± 5% pred	−24 ± 69 m	2 ± 16

Coils	Slebos et al. 2012 [14]	Prospective, noncontrolled		6 months	15 ± 17%	84 ± 73 m	−15 ± 12
	Shah et al. 2013 [15]	RCT	Treatment group ()	3 months	14%	52 m	−8
	Zoumot et al. 2015 [16]	RCT	Treatment group ()	12 months	9 ± 22%	34 ± 52 m	−6 ± 14

BioLVR	Criner et al. 2009 [17]	Open-label, multicenter, non-RCT	Low-dose hydrogel ()	6 months	6.7 ± 12.9%	25.5 ± 53.2 m	−6.9 ± 8.8
	Criner et al. 2009 [17]	Open-label, multicenter, non-RCT	High-dose hydrogel ()	6 months	15.6 ± 16.8%	9.9 ± 51.2 m	−9.7 ± 18.8
	Herth et al. 2010 [18]	Open-label, multicenter, non-RCT		3 months	3.3 ± 3.2%	10.8 ± 8.8%	−7.8 ± 3.7
	Magnussen et al. 2012 [19]	Retrospective analysis from multicenter non-RCTs		12 weeks	19.1 ± 21.5% (0.18 ± 0.22 L)	30.9 ± 50.2 m	−11.6 ± 12.4
	Kramer et al. 2012 [20]	Multicenter open-label non-RCT		12 months	25.0 ± 33.4%	8.6 ± 65.2 m	−7.0 ± 15.8

BTVA	Snell et al. 2012 [21]	Prospective, noncontrolled		6 months	17%	47 m	−14
BTVA	Herth et al. 2012 [22]	Two multicenter single-arm prospective studies		12 months	86 ± 174 mL	18.5 ± 63.7 m	−11 ± 14

Stents	Cardoso et al. 2007 [23]	Multicenter non-RCT		6 months	0.6%	−12 m	−1.8
	Shah et al. 2011 [24]	Multicenter RCT		12 months	−20 ± 200 mL	−21 m	−1
	Shah et al. 2011 [24]	Multicenter RCT		12 months	−0.15 ± 7%	−21 m	−1

Values for changes (Δ) are means ± SD.
6-MWD: 6 min walking distance; BTVA: bronchial thermal vapour ablation; FEV₁: forced expiratory volume in one second; RCT: randomized controlled trial; SGRQ: St. George’s Respiratory Questionnaire.