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Reference/location | Cohort definition | Exposure assessment | Talc exposure | Other exposures | Smoking |
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Bulbulyan et al., Russia, 1999 [6] | 3473 female employees of two printing plants employed >2 years, 1978–93, followed up for cancer incidence from 1979 to 1993 | Area air sampling data plus job description data; job type: compositors, press operators, bookbinders, and other | Talc with asbestos contamination | Paper dust, benzene, aromatic hydrocarbons, carbon black, lead | Unknown |
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Coggiola et al., Italy, 2003 [7] | 1795 male employees from Italian talc mine employed >1 year, 1946–1995, followed up from 1946 to 1995 | Job histories from plant records; job type: miner versus miller; duration of exposure and time since first exposure (years) | Talc without asbestiform fibers; >200 mppcf in 1950, <5 mppcf in 1965 | Quartz, radon (miners) | 44%–47% smokers compared to 34% in Italian population (1994) |
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Fu and Zhang, China, 1992 [8] | 1357 male workers in Haichen talc mines employed >1 year in January 1974, followed up through 1988 | Job histories from factory records; job type: miner versus miller; medical exam records in local hospitals; duration of exposure and time since first exposure (years) | Talc without asbestiform fibers | Radon (miners) | 64% smokers |
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Honda et al., USA, 2002 [9] | 782 male employees from a New York talc mining and milling facility employed >1 day, 1948–1989, followed up from 1950 to 1989 | Cumulative respirable dust exposure estimation for individual subjects from a job-exposure matrix consisting of estimates of respirable dust concentrations for all work area and calendar year combinations | Talc with asbestos contamination; 0.1–1.7 mg/m3 | Asbestos, nonasbestiform amphibole, taconite | Unknown |
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Li and Yu, China, 1998 [10] | 934 male and 664 female workers of a Shanghai rubber factory who entered a screening program for heart disease in 1972, followed up from 1973 to 1995 | Based on information on work history obtained from the records of a screening program for heart disease | Talc with asbestos contamination was exposed to the workers engaged in the production of tires and inner tubes | Nitrosamine, multiple solvents | 63% for male workers and 9% for female workers compared to 46% for men and 5% for women in general population |
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McLean et al., multinational, 2006 [11] | 60,468 workers employed > 1 year in the pulp and paper industry in 11 countries, 1920–1996; followed up through 1996 | Exposure was estimated at the department level based on assessments of an international panel of industrial hygiene experts through detailed company questionnaires | Talc with asbestos contamination, categorized into ever-exposure and ever-high-exposure levels | Paper dust, asbestos, multiple volatile, and nonvolatile organochlorine compounds | Unknown |
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Nie et al., China, 1992 [12] | 8654 male and 3564 female pottery workers (412 with talc exposure) employed >1 year, 1972–1974, followed up through 1989 | Area air sampling data plus work histories; minerals analyzed by phase contrast microscopy | Talc without asbestiform fibers; 1–18% of total dust | Silica | Unknown |
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Stern et al., USA, 2001 [13] | 12873 males of the Operative Plasterers’ and Cement Masons’ International Association, 1972–1996; followed up through 1996 | Potential worker exposures were based on a representative sample of 4,500 U.S. industrial facilities conducted by the USA National Occupational Exposure Survey (NOES) during 1981–1983 | Talc with asbestos contamination | Cement dust, 1,1,1- trichloroethylene, quartz, sand, mica, silica, attapulgite, asphalt, brick clay, carbon tetrachloride, dioxane, tetrachloroethylene, fiberglass | Unknown |
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Selevan et al., USA, 1979 [14] | 388 male talc workers from 5 talc producing companies in Vermont employed >1 year, 1940–1969, followed up from 1940 to 1975 | Based on historical data that demonstrated past exposure levels far exceeded the standard for nonfibrous talc of 20 mppcf | Talc without asbestiform fibers; commonly >20 mppcf | Quartz (<0.25%) | Unknown |
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Straif et al., Germany, 2000 [15] | 8933 male employees from 5 German rubber plants employed >1 year retired or active in 1981 followed up from 1981 to 1991 | Work histories reconstructed from cost center codes plus semiquantitative cumulative exposure | Talc with asbestos contamination | Asbestos, nitrosamines, carbonblack | Unknown |
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Thomas and Stewart, USA, 1987 [16] | 2055 white male workers from American pottery factory employed >1 year, 1939–66; mortality follow-up through 1981 | Exposure to silica and talc assessed qualitatively by job title and department by industrial hygienist | Nonfibrous talc (a subgroup of workers exposed only to silica and nonfibrous talc) | Quartz | Unknown |
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Wergeland et al., Norway, 1990 [17] | 389 male employees from a Norwegian talc mill employed >2 years, 1935–1972, followed up from 1953 to 1987 | Subjective assessment of exposure by experienced employees; workers classified based on low, medium, high, and unknown exposure by total duration of employment in jobs | Talc without asbestiform fibers. For miners: 0.94–97.35 mg/m3 peaked at 319 mg/m3 0.2–0.9 f/ml. For millers: 1.4–54.1 mg/m3 peaked at 109 mg/m3 0.2–0.9 f/ml | Radon (miners) | 76% smokers (miners) |
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Wild et al., Austria, 2002 [18] | 542 male workers of an Austrian talc producing company employed >1 year, 1972–1995, followed up from 1972 to 1995 | Semiquantitative, site-specific job-exposure matrix based on personal dust measurements and descriptions from employees | Talc without asbestiform fibers; >30 mg/m3 before 1960, 5–30 mg/m3 until 1980, <5 mg/m3 thereafter | Quartz (<3%) | 42% smokers |
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Wild et al., France, 2002 [18] | 945 male employees from a French talc mill employed >1 year, 1945–1994, followed up from 1968 to 1995 | Semiquantitative, site-specific job-exposure matrix based on personal dust measurements and descriptions from employees | Talc without asbestiform fibers; >30 mg/m3 before 1970s, 5–30 mg/m3 until 1990, <5 mg/m3 thereafter | Quartz (<3%) | 59% smokers compared to 39% French population (1986) |
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