Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis

Table 2

Results of the meta-analysis comparing OSA patients and healthy controls. RVID: right ventricular basal diameter measured at end-diastole; RVWT: right ventricular wall thickness; RV MPI: right ventricular myocardial performance index; RV S’: tricuspid annular systolic velocity; TAPSE: tricuspid annular plane systolic excursion; RV FAC: right ventricular fractional area change; OSA: obstructive sleep apnea; WMD: weighted mean difference; CI: confidence interval.

Echocardiographic parameters	Number of studies	OSA/control	WMD (95% CI)	value	Study heterogeneity			Egger’s test value
							value
RVID	16	902/596	2.49 (1.62, 3.37)	0.000	96.8%	647.61	0.000	0.001
RVWT	9	579/397	0.82 (0.51, 1.13)	0.000	95.6%	344.56	0.000	0.671
RV MPI	14	864/434	0.08 (0.06, 0.10)	0.000	84.1%	157.39	0.000	0.150
RV S’	14	639/391	−0.95 (−1.59, −0.32)	0.003	88.4%	190.21	0.000	0.347
TAPSE	11	655/378	−1.76 (−2.73, −0.78)	0.000	89.3%	187.24	0.000	0.462
RV FAC	6	422/239	−3.16 (−5.60, −0.73)	0.011	80.2%	70.83	0.000	0.006