Comparison of Respiratory Pathogen Detection in Upper versus Lower Respiratory Tract Samples Using the BioFire FilmArray Respiratory Panel in the Immunocompromised Host

Table 5

Yield of routine microbiology studies in bronchoalveolar lavage fluid collected from immunocompromised () and immunocompetent () patients.

Patient group and FilmArray result	Total number	Number (%) of BAL fluid samples that were positive by a routine microbiology test^a
ICH	100	25^b (25.0%)
Positive FARP	32	10 (31.3%)
Negative FARP	68	15 (23.5%)
Non-ICH	25	11^c (44.0%)
Positive FARP	2	1 (50.0%)
Negative FARP	23	10 (43.5%)

No., number; BAL, bronchoalveolar lavage; ICH, immunocompromised host; FARP, FilmArray Respiratory Panel; ^aroutine microbiology testing included Gram staining, fungal smear, acid-fast smear, routine cultures (bacterial, fungal, viral, and mycobacterial), real-time PCR for influenza A/B, respiratory syncytial virus (RSV), Pneumocystis jirovecii, adenovirus, and Legionella spp.; ^borganisms recovered/detected: Aspergillus spp. (), cytomegalovirus (), Pseudomonas spp. (), Klebsiella spp. (), S. aureus (), methicillin-resistant Staphylococcus aureus (), Serratia marcescens (), Pneumocystis jirovecii (), Scopulariopsis (), Bordetella bronchiseptica (), Haemophilus influenzae (), Stenotrophomonas maltophilia (), Proteus mirabilis (), Mycobacterium avium complex (), and Histoplasma capsulatum () (three patients had more than one pathogen detected); ^corganisms recovered/detected: Mycobacterium avium complex (), Aspergillus spp. (), Staphylococcus aureus (), Stenotrophomonas maltophilia (), Mycobacterium abscessus group (), Achromobacter spp. (), Haemophilus influenzae (), Citrobacter spp. (), and Klebsiella spp. () (four patients had more than one pathogen detected).