Adrenal Insufficiency in Cystic Fibrosis: A Rare Phenomenon?
Table 3
Clinical characteristics of adrenal insufficient patients with CF with and without systemic corticosteroids .
Systemic corticosteroids
Yes
No
value
Demographic
Number of patients
14
19
Sex (% men)
35.7
57.9
0.215
Age (years)
36.0 (21.0–55.0)
26.0 (19.0–39.0)
0.019
Weight (kg)
58.8 (50.0–79.1)
61.2 (41.1–72.8)
0.913
BMI (kg/m2)
21.3 (19.1–27.4)
21.7 (17.1–27.5)
0.971
Genotype (% yes)
Homozygote delF508
57.1
63.2
Heterozygote delF508
35.7
26.3
0.825
Others
7.1
10.5
Comorbidities
Glucose tolerance (% yes)
Normal
7.1
15.8
0.459
Dysglycemic
92.9
84.2
0.459
Pancreatic insufficiency (% yes)
71.4
100.0
0.014
Hepatic dysfunction (% yes)
21.4
36.8
0.208
Home oxygen therapy (% yes)
7.1
21.1
0.278
Noninvasive ventilation (% yes)
0
10.5
0.217
ABPA (% yes)
64.3
0
≤0.001
BMI, body mass index; dysglycemic is presence of either glucose intolerance or diabetes; hepatic dysfunction is either abnormal level of hepatic enzymes or presence of cirrhosis; ABPA, allergic bronchopulmonary aspergillosis. Median and interval range are shown. value < 0.05 represents Mann-Whitney Student’s t-test. Chi2 regression analysis.
