Adrenal Insufficiency in Cystic Fibrosis: A Rare Phenomenon?
Table 4
Paraclinical characteristics of adrenal insufficient patients with CF with and without systemic corticosteroids .
Systemic corticosteroids
Yes
No
value
Pulmonary function test
FEV1 (% pred)
56.9 (28.6–73.7)
44.1 (27.5–82.6)
0.536
FVC (% pred)
75.3 (51.0–96.4)
68.6 (56.4–97.8)
0.466
RV (% pred)
188.5 (128.0–221.0)
238.0 (126.0–406.0)
0.051
Biochemistry
Fasting cortisol (nmol/L)
134.0 (25.0–254.0)
169.5 (12.0–335.0)
0.323
Cortisol (nmol/L)
1 μg functional cortrosyn test (n)
10
18
0 minutes
124.5 (25.0–219.0)
167.0 (10.0–382.0)
0.415
30 minutes
314.0 (86.0–425.0)
398.5 (25.0–491.0)
0.179
60 minutes
279.0 (64.0–457.0)
315.5.0 (23.0–425.0)
0.388
250 μg functional cortrosyn test (n)
1
1
0 minutes
26.0
291.0
NA
30 minutes
179.0
472.0
NA
60 minutes
238.0
381.0
NA
Hematology
WBC (109/L)
9.4 (4.9–17.5)
7.6 (2.6–15.0)
0.074
Medication
Inhaled corticosteroids (% yes)
92.9
94.7
0.823
Inhaled chronic antibiotic therapy (% yes)
78.6
78.9
0.979
Medical history
Number of hospitalizations (2 years prior to diagnosis)
2.0 (0–6.0)
4.0 (0–11)
0.151
Number of intravenous antibiotic treatments (2 years prior to diagnosis)
2.5 (0–7.0)
4.0 (0–11)
0.212
Colonization/microbiology
Non-TB mycobacteria (% yes)
7.1
0
0.244
Staphylococcus aureus (% yes)
42.9
36.8
0.731
Pseudomonas aeruginosa (% yes)
71.4
89.5
0.191
Aspergillus and fungi (% yes)
50.0
47.4
0.883
Stenotrophomonas maltophilia (% yes)
28.6
31.6
0.826
Others (% yes)
14.3
10.5
0.747
FEV1, forced expiratory volume-one second; FVC, forced vital capacity; RV, residual volume; WBC, white blood cell count; TB, tuberculous; NA, not applicable. Median and interval range are shown. value < 0.05 represents Mann-Whitney Student’s t-test.
