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Canadian Respiratory Journal
Volume 2018, Article ID 3640967, 5 pages
https://doi.org/10.1155/2018/3640967
Research Article

Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease

1Department of Pulmonary Medicine, St. Luke’s International University, St. Luke’s International Hospital, Tokyo, Japan
2Center for Clinical Epidemiology, St. Luke’s International University, St. Luke’s International Hospital, Tokyo, Japan

Correspondence should be addressed to Kazushige Shiraishi; pj.ca.oykot-u.m@4210arihs

Received 15 August 2017; Revised 14 November 2017; Accepted 21 November 2017; Published 23 January 2018

Academic Editor: Akiteru Goto

Copyright © 2018 Kazushige Shiraishi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. C. Mathai and S. K. Danoff, “Management of interstitial lung disease associated with connective tissue disease,” BMJ, vol. 352, p. h6819, 2016. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Kobayashi and S. Kitamura, “KL-6: a serum marker for interstitial pneumonia,” Chest, vol. 108, no. 2, pp. 311–315, 1995. View at Publisher · View at Google Scholar
  3. N. Ishikawa, N. Hattori, A. Yokoyama, and N. Kohno, “Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases,” Respiratory Investigation, vol. 50, no. 1, pp. 3–13, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. K. A. Myers and D. R. Farquhar, “The rational clinical examination. Does this patient have clubbing?” JAMA, vol. 286, no. 3, pp. 341–347, 2001. View at Publisher · View at Google Scholar
  5. K. E. Spicknall, M. J. Zirwas, and J. C. English III, “Clubbing: an update on diagnosis, differential diagnosis, pathophysiology, and clinical relevance,” Journal of the American Academy of Dermatology, vol. 52, no. 6, pp. 1020–1028, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. C. J. Ryerson, E. Vittinghoff, B. Ley et al., “Predicting survival across chronic interstitial lung disease: the ILD-GAP model,” Chest, vol. 145, no. 4, pp. 723–728, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. R. P. Baughman, K. L. Gunther, J. A. Buchsbaum, and E. E. Lower, “Prevalence of digital clubbing in bronchogenic carcinoma by a new digital index,” Clinical and Experimental Rheumatology, vol. 16, no. 1, pp. 21–26, 1998. View at Google Scholar
  8. G. Raghu, H. R. Collard, J. J. Egan et al., “An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management,” American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 6, pp. 788–824, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. J. McDonagh, M. Greaves, A. R. Wright, C. Heycock, J. P. Owen, and C. Kelly, “High resolution computed tomography of the lungs in patients with rheumatoid arthritis and interstitial lung disease,” British Journal of Rheumatology, vol. 33, no. 2, pp. 118–122, 1994. View at Publisher · View at Google Scholar · View at Scopus
  10. B. A. Rajasekaran, D. Shovlin, P. Lord, and C. A. Kelly, “Interstitial lung disease in patients with rheumatoid arthritis: a comparison with cryptogenic fibrosing alveolitis,” Rheumatology, vol. 40, no. 9, pp. 1022–1025, 2001. View at Publisher · View at Google Scholar
  11. X. Li, C. Chen, J. Xu et al., “Nonspecific interstitial pneumonia and usual interstitial pneumonia: comparison of the clinicopathologic features and prognosis,” Journal of Thoracic Disease, vol. 6, no. 10, pp. 1476–1481, 2014. View at Google Scholar
  12. B. Bradley, H. M. Branley, J. J. Egan et al., “Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society,” Thorax, vol. 63, no. 5, pp. v1–v58, 2008. View at Google Scholar
  13. S. Ishioka, K. Nakamura, A. Maeda et al., “Clinical evaluation of idiopathic interstitial pneumonia and interstitial pneumonia associated with collagen vascular disease using logistic regression analysis,” Internal Medicine, vol. 39, no. 3, pp. 213–219, 2000. View at Publisher · View at Google Scholar
  14. S. Uppal, C. P. Diggle, I. M. Carr et al., “Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy,” Nature Genetics, vol. 40, no. 6, pp. 789–793, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. K. R. Kozak, G. L. Milne, S. M. Bentzen, and T. I. Yock, “Elevation of prostaglandin E2 in lung cancer patients with digital clubbing,” Journal of Thoracic Oncology, vol. 7, no. 12, pp. 1877-1878, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. R. T. Dackor, J. Cheng, J. W. Voltz et al., “Prostaglandin E2 protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction,” American Journal of Physiology–Lung Cellular and Molecular Physiology, vol. 301, no. 5, pp. L645–L655, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Lappi-Blanco, R. Kaarteenaho-Wiik, P. K. Maasilta, S. Anttila, P. Pääkkö, and H. J. Wolff, “COX-2 is widely expressed in metaplastic epithelium in pulmonary fibrous disorders,” American Journal of Clinical Pathology, vol. 126, no. 5, pp. 717–724, 2006. View at Publisher · View at Google Scholar
  18. K. Shiraishi, T. Jinta, N. Nishimura et al., “Digital clubbing is associated with higher serum KL-6 levels and lower pulmonary function in patients with interstitial lung disease,” in Proceedings of the poster presented at the American Thoracic Society International Conference,, San Francisco, CA, USA, May 2016, http://www.atsjournals.org/doi/pdf/10.1164/ajrccm-conference.2016.193.1_MeetingAbstracts.A5006.