The Function of Ophiocordyceps sinensis in Airway Epithelial Cell Senescence in a Rat COPD Model

Figure 2

The expression of P16 and P21 in the airway epithelial cells of COPD rat models. (a) The pathological structure changes of airway in COPD rats were observed by HE staining (HE, 200x). In the control group, the airway epithelium structure was complete, and cell fall off, cilia lodging, goblet cell hyperplasia, and phlegm retention were not obvious. In the COPD group, airway epithelial cells fall off partly, and mucosal hyperemia, cilium adhesion or lodging, goblet cell hyperplasia (black arrow), mucus secretion exuberant and large amounts of mucus retention (white arrow), and fibrous tissue hyperplasia (triangle) around the trachea and submucosa were obvious. In the COPD + CS group (O. sinensis treatment group), in the airway epithelium, cilia lodging, hyperplasia of goblet cells, mucus gland secretion, and submucosal fibrous tissue hyperplasia were also reduced. (b) The expression of P16 and P21 in the airway epithelium of the COPD group and COPD + CS group were detected by IHC (200x). (c) Quantitative analysis of P16 and P21 expression in the COPD group and COPD + CS group. ; .

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