Table of Contents Author Guidelines Submit a Manuscript
Canadian Respiratory Journal
Volume 2018 (2018), Article ID 6080348, 9 pages
https://doi.org/10.1155/2018/6080348
Research Article

The Function of Ophiocordyceps sinensis in Airway Epithelial Cell Senescence in a Rat COPD Model

1Department of Respiratory Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China
2Department of Respiratory Medicine, Shandong Chest Hospital, Jinan, Shandong, China

Correspondence should be addressed to Liang Dong; moc.621@6055ld

Received 19 September 2017; Revised 10 December 2017; Accepted 31 January 2018; Published 1 April 2018

Academic Editor: Frederik Trinkmann

Copyright © 2018 Xiaohui Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Schuliga, “NF-kappaB signaling in chronic inflammatory airway disease,” Biomolecules, vol. 5, no. 3, pp. 1266–1283, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Yue and H. Yao, “Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases,” British Journal of Pharmacology, vol. 173, no. 15, pp. 2305–2318, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Wu, F. Dong, R. A. Wang et al., “Central role of cellular senescence in TSLP-induced airway remodeling in asthma,” PLoS One, vol. 8, no. 10, Article ID e77795, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. R. M. Tuder, J. A. Kern, and Y. E. Miller, “Senescence in chronic obstructive pulmonary disease,” Proceedings of the American Thoracic Society, vol. 9, no. 2, pp. 62-63, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Liu, J. Wu, A. Li et al., “The inhibitory mechanism of Cordyceps sinensis on cigarette smoke extract-induced senescence in human bronchial epithelial cells,” International Journal of Chronic Obstructive Pulmonary Disease, vol. 11, pp. 1721–1731, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Campisi, J. K. Andersen, P. Kapahi, and S. Melov, “Cellular senescence: a link between cancer and age-related degenerative disease?” Seminars in Cancer Biology, vol. 21, pp. 354–359, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. D. V. Ziegler, C. D. Wiley, and M. C. Velarde, “Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging,” Aging Cell, vol. 14, no. 1, pp. 1–7, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. P. J. Barnes, “Mechanisms of development of multimorbidity in the elderly,” European Respiratory Journal, vol. 45, no. 3, pp. 790–806, 2015. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Bagdonas, J. Raudoniute, I. Bruzauskaite, and R. Aldonyte, “Novel aspects of pathogenesis and regeneration mechanisms in COPD,” International Journal of Chronic Obstructive Pulmonary Disease, vol. 10, pp. 995–1013, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Liu, J. Wang, W. Wang, H. Zhang, X. Zhang, and C. Han, “The chemical constituents and pharmacological actions of Cordyceps sinensis,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 575063, 12 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Shaykhiev and R. G. Crystal, “Early events in the pathogenesis of chronic obstructive pulmonary disease: smoking-induced reprogramming of airway epithelial basal progenitor cells,” Annals of the American Thoracic Society, vol. 11, no. 5, pp. S252–S258, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Al Faraj, A. Sultana Shaik, M. A. Pureza, M. Alnafea, and R. Halwani, “Preferential macrophage recruitment and polarization in LPS-induced animal model for COPD: noninvasive tracking using MRI,” PLoS One, vol. 9, no. 3, Article ID e90829, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Ji, Y. Wang, X. Li, and Z. Qian, “Up-regulation of ICAM-1mRNA and IL-1βmRNA in lung tissues of a rat model of COPD,” International Journal of Clinical and Experimental Medicine, vol. 8, no. 11, pp. 21956–21963, 2015. View at Google Scholar
  14. A. Bernadotte, V. M. Mikhelson, and I. M. Spivak, “Markers of cellular senescence: telomere shortening as a marker of cellular senescence,” Aging, vol. 8, no. 1, pp. 3–11, 2016. View at Publisher · View at Google Scholar
  15. H. H. Al-Khalaf and A. Aboussekhra, “p16 (INK4A) induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1,” Molecular Carcinogenesis, vol. 56, no. 3, pp. 985–999, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. W. I. De Boer, H. Yao, and I. Rahman, “Future therapeutic treatment of COPD: struggle between oxidants and cytokines,” International Journal of Chronic Obstructive Pulmonary Disease, vol. 2, no. 3, pp. 205–228, 2007. View at Google Scholar
  17. V. Conti, G. Corbi, V. Manzo, G. Pelaia, A. Filippelli, and A. Vatrella, “Sirtuin 1 and aging theory for chronic obstructive pulmonary disease,” Analytical Cellular Pathology, vol. 2015, Article ID 897327, 8 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. J. M. Park, J. S. Lee, K. R. Lee, S. J. Ha, and E. K. Hong, “Cordyceps militaris extract protects human dermal fibroblasts against oxidative stress-induced apoptosis and premature senescence,” Nutrients, vol. 6, no. 9, pp. 3711–3726, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Singh, R. Tulsawani, P. Koganti, A. Chauhan, M. Manickam, and K. Misra, “Cordyceps sinensis increases hypoxia tolerance by inducing heme oxygenase-1 and metallothionein via Nrf2 activation in human lung epithelial cells,” BioMed Research International, vol. 2013, Article ID 569206, 13 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Gu, H. Johno, S. Nakajima, T. Yoshitomi, S. Takahashi, and M. Kitamura, “Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2α and suppression of Sp1,” Toxicological Sciences, vol. 134, no. 2, pp. 345–354, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. G. S. Gu, J. A. Ren, G. W. Li, Y. J. Yuan, N. Li, and J. S. Li, “Cordyceps sinensis preserves intestinal mucosal barrier and may be an adjunct therapy in endotoxin-induced sepsis rat model: a pilot study,” International Journal of Clinical and Experimental Medicine, vol. 8, no. 5, pp. 7333–7341, 2015. View at Google Scholar
  22. Y. S. Prakash, “Airway smooth muscle in airway reactivity and remodeling: what have we learned?” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 305, no. 12, pp. L912–L933, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. S. S. Sohal, C. Ward, W. Danial, R. Wood-Baker, and E. H. Walters, “Recent advances in understanding inflammation and remodeling in the airways in chronic obstructive pulmonary disease,” Expert Review of Respiratory Medicine, vol. 7, no. 3, pp. 275–288, 2013. View at Publisher · View at Google Scholar · View at Scopus