Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective Study

Table 3

The diagnostic yield, size, and quality of samples and complications.

Semirigid pleuroscope patients (n = 51)	Close pleural biopsy	Flexible forceps biopsy	Cryoprobe biopsy	Cytology cell block
Diagnostic yield	25 (27.1)	84 (91.3)	91 (98.9)	32 (34.8)
For IHC stain	12 (13.0)	80 (87.0)	91 (98.9)	12 (13.0)
Size, mm	1.9 ± 1.0	4.2 ± 2.3	9.4 ± 4.9	—
Complication
Bleeding
Nil	92	86	84	0
Mild	0	6	8	0
Moderate to severe	0	0	0	0

Nil bleeding: slight, self-limited; mild bleeding: needing bosmin injection; moderate to severe: needing coagulation or APC. value of diagnostic yield: close pleural biopsy versus flexible forceps biopsy: <0.0001; close pleural biopsy versus cryoprobe biopsy: <0.0001; close pleural biopsy versus cytology cell block: 0.929; flexible forceps biopsy versus cryoprobe biopsy: 0.017. value of IHC stain: close pleural biopsy versus flexible forceps biopsy: <0.0001; close pleural biopsy versus cryoprobe biopsy: <0.0001; close pleural biopsy versus cytology cell block: 0.998; flexible forceps biopsy versus cryoprobe biopsy: 0.001. value of size: close pleural biopsy versus flexible forceps biopsy: <0.0001; close pleural biopsy versus cryoprobe biopsy: <0.0001; flexible forceps biopsy versus cryoprobe biopsy: <0.0001.