Canadian Respiratory Journal / 2018 / Article / Tab 1

Research Article

Cardiac Magnetic Resonance Imaging for Diagnosis of Cardiac Sarcoidosis: A Meta-Analysis

Table 1

Review of the literature.

StudyYearCountryStudy populationStandard clinical investigationsCMR diagnostic criteriaReference test

Smedema et al. [22]2005The Netherlands58 patients with histologically proven pulmonary sarcoidosisECGHolterUCGSPECTHyperenhancement on DE-MRIJMHW
Ohira et al. [23]2008Japan21 consecutive patients with suspected cardiac sarcoidosisECGHolterUCG
99mTc-sestamibi scintigraphy
18F-FDG PET stress ECG (if needed) nuclear cardiac testing (if needed) coronary angiography (if needed)
High signal intensity on T2WI hyperenhancement on DE-MRIJMHW
Patel et al. [18]2009America81 consecutive biopsy-proven sarcoidosis patientsECG cardiac-imaging study (at least one, non-CMR) cardiac biopsy (if performed)
X-ray coronary angiography if performed
Hyperenhancement on DE-MRIJMHW
Manins et al. [19]2009Australia20 consecutive biopsy-proven sarcoidosis patients with a suspicion of CSECGHolterUCGGallium
-67 radionuclide investigation (if performed)
PET (if performed)
cardiac biopsy (if performed)
Hyperenhancement on DE-MRI showed regional wall motion abnormalities with regional fibrosis and edemaJMHW
Soussan et al. [15]2013France35 consecutive biopsy-proven sarcoidosis patients with a suspicion of CSECGHolterUCGPET
(if performed)
Hyperenhancement on DE-MRI spared the subendocardium and remained limited to the middle or epicardial portion of the myocardic wall or transmuralJMHW
Yokoyama et al. [17]2015Japan125 consecutive patients with suspected CSsACE
C-reactive protein
ECG (if needed)
UCG (if needed)
PET myocardial perfusion scintigraphy (if needed)
Hyperenhancement on DE-MRIJMHW
Kouranos et al. [14]2017Greece and the United Kingdom321 consecutive biopsy-proven sarcoidosis patients (all Caucasians)ECG
67Gallium scintigraphy (within 3 months) chest Radiograph (within 3 months) pulmonary Function tests (within 3 months)
Hyperenhancement on DE-MRI and regional wall motion abnormalitiesHRS consensus criteria and JMHW
Stanton et al. [16]2017Australia46 consecutive patients with biopsy-proven sarcoidosisECG
Holter (if performed)
exercise stress tests (if performed)
PET (if performed)
Hyperenhancement on DE-MRIJMHW

ECG: electrocardiogram; UCG: ultrasound cardiogram; SPECT: perfusion single photon emission computed tomography; DE-MRI: delayed enhancement magnetic resonance imaging; JMHW: the guidelines of the Japanese Ministry of Health and Welfare; sACE: serum angiotensin-converting enzyme; 18F-FDG: 18F-fluoro-2-deoxy-D-glucose, BNP: B-type natriuretic peptide.