Study of Clinical Characteristics and Cytokine Profiles of Asthmatic Children with Rhinovirus Infection during Acute Asthma Exacerbation at National Hospital of Pediatrics
Table 3
Comparison of cytokine concentration of study subjects classified by positive or negative rhinovirus infection versus control.
Cytokines (pg/mL)
Control ()
Asthma with RV− ()
Asthma with RV+ ()
Non-Th2-related cytokines
IL-2
4.21 ± 2.88
1.27 ± 2.43
1.86 ± 3.17
<0.05,, NS
IL-8
7.58 ± 7.40
6.02 ± 5.65
10.37 ± 15.42
NS,,
IL-10
5.28 ± 9.78
13.44 ± 16.52
4.57 ± 6.87
<0.05,; NS
TNF-α
3.61 ± 8.46
7.94 ± 37.02
7.65 ± 32.13
<0.05,, NS
IFN-γ
77.56 ± 66.43
46.47 ± 68.13
63.50 ± 53.94
NS,,
Th2-related cytokines
GM-CSF
18.93 ± 48.54
14.70 ± 29.46
38.04 ± 44.79
NS,,
IL-4
0.86 ± 0.32
3.91 ± 1.30
4.32 ± 2.56
<0.05,; NS
IL-5
0.89 ± 0.78
1.85 ± 2.16
2.79 ± 2.73
<0.05,,
IL-13
2.02 ± 1.92
2.05 ± 1.51
3.99 ± 6.46
NS; <0.05,
RV: rhinovirus; RV+: positive RV infection; RV−: negative RV infection. Asthma with RV− versus control; asthma with RV+ versus control; asthma with RV+ versus asthma with RV−.
