Study of Clinical Characteristics and Cytokine Profiles of Asthmatic Children with Rhinovirus Infection during Acute Asthma Exacerbation at National Hospital of Pediatrics

Table 4

Cytokine profile classified by RV infection and asthma severity.

PAS	Asthma with RV^−				Asthma with RV^+
	Mild	Moderate	Severe		Mild	Moderate	Severe
Non-Th2-related cytokines
IL-2	0.68 ± 0.84	3.13 ± 10.29	0.59 ± 1.09	NS^,^,	3.65 ± 6.80	2.12 ± 8.92	1.76 ± 3.71	NS^,^,
IL-8	7.11 ± 8.35	3.96 ± 1.82	5.24 ± 4.11	NS^,^,	8.96 ± 6.39	8.31 ± 4.63	13.86 ± 22.84	NS^,^,
IL-10	9.36 ± 21.75	34.07 ± 105.7	3.89 ± 37.20	NS^,^,	4.94 ± 2.74	3.82 ± 4.28	5.52 ± 9.48	NS^,^,
TNF-α	9.01 ± 26.11	18.90 ± 66.49	10.06 ± 1.10	NS^,^,	1.68 ± 2.28	1.81 ± 3.20	15.44 ± 38.38	NS; <0.05^,
IFN-γ	37.49 ± 51.02	81.32 ± 168.6	36.98 ± 53.87	NS^,^,	122.25 ± 226.1	48.15 ± 76.70	65.78 ± 202.1	<0.05^,; NS
Th2-related cytokines
GM-CSF	18.15 ± 32.08	19.47 ± 40.37	12.59 ± 21.46	NS^,^,	102.38 ± 104.6	24.67 ± 44.35	46.59 ± 148.0	NS^,^,
IL-4	4.24 ± 5.12	4.82 ± 6.34	3.93 ± 8.23	NS^,^,	3.03 ± 6,65	4,18 ± 8,23	4,23 ± 3,56	NS^,^,
IL-5	1.66 ± 1.40	2.50 ± 2.57	1.98 ± 2.53	NS^,^,	4.42 ± 5.29	2.04 ± 1.89	2.48 ± 2.96	NS^,^,
IL-13	2.04 ± 1.54	2.58 ± 1.64	1.83 ± 1.62	NS^,^,	2.86 ± 2.84	2.94 ± 28.20	5.11 ± 9.62	NS^,^,

RV: rhinovirus; RV⁺: positive RV infection; RV⁻: negative RV infection. Moderate PAS versus mild PAS; severe PAS versus mild PAS; severe PAS versus moderate PAS. PAS: pediatric asthma scores consisted of five components as described in footnote of Table 1.