Research Article
Daily Chronic Intermittent Hypobaric Hypoxia Does Not Induce Chronic Increase in Pulmonary Arterial Pressure Assessed by Echocardiography
Table 4
High-altitude echocardiography and blood gas analysis at rest and during exercise
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| | High altitude | CIHH | Control | value |
| | Laboratory | | | | | Pro-BNP (pg/ml) | 39.5 ± 27.2 | 43.0 ± 41.2 | 0.85 | | Endothelin-1 (pg/ml) | 1.84 ± 0.45 | 2.27 ± 1.38 | 0.37 | | Echocardiography at rest | | | | | sPAP, not measurable at rest (n) | 0 | 0 | | | sPAP (mmHg) | 19.6 ± 3.3 | 20.1 ± 4.1 | 0.82 | | TAPSE (mm) | 21 ± 3.9 | 22.1 ± 4.5 | 0.80 | | Vital signs at rest altitude | | | | | HR (bpm) | 79.4 ± 21 | 88.9 ± 22.2 | 0.41 | | Mean RR (mmHg) | 104.0 ± 9.4 | 98.4 ± 10.8 | 0.31 | | Blood gas analysis at rest altitude | | | | | pO2 (mmHg) | 70.1 ± 7.3 | 63.2 ± 7.6 | 0.10 | | pCO2 (mmHg) | 28.5 ± 2.3 | 31.8 ± 2.4 | 0.01 | | pH | 7.44 ± 0.01 | 7.44 ± 0.01 | 0.46 | | BE (mmol) | −3.64 ± 1.12 | −2.30 ± 1.32 | 0.05 | | SaO2 (%) | 93.1 ± 1.0 | 91.4 ± 2.5 | 0.10 | | AaDO2 | 8.1 ± 7.6 | 11.2 ± 6.8 | 0.43 | | Echocardiography exertion 75 W | | | | | sPAP (mmHg) | 26.3 ± 4.1 | 33.6 ± 7.2 | 0.04 | | TAPSE (mm) | 26.2 ± 2.8 | 25.6 ± 4.6 | 0.80 | | SpO2 (%) | 91.83 ± 1.47 | 87.38 ± 4.41 | 0.03 |
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CIHH: chronic intermittent hypobaric hypoxia; sPAP: systolic pulmonary arterial pressure; TAPSE: tricuspid annular plane systolic excursion; pO 2: oxygen partial pressure; pCO 2: carbon dioxide partial pressure; BE: base excess; SaO 2: arterial oxygen saturation; SpO 2: peripheral oxygen saturation; by t-test. |
