Table 4: Baseline and follow-up data of parameters of echocardiography, hematology, and 6MWD.

Baseline1 year2 yearDifference 1Difference 2
BosentanAmbrisentanBosentanAmbrisentanBosentanAmbrisentanBosentanAmbrisentanBosentanAmbrisentan

6MWD (m)432.5 ± 79.1511.7 ± 41.4422.3 ± 81.1517.3 ± 60.8409.0 ± 92.0520.0 ± 72.410.3 ± 14.5−5.6 ± 38.913.3 ± 29.6−2.8 ± 21.2
NT-proBNP (pg/ml)805.1 ± 440.4516.6 ± 556.3960.8 ± 673.8604.7 ± 1247.61113.8 ± 902.3334.3 ± 535.7−155.4 ± 700.7−104.8 ± 1375.0−153.0 ± 376.9270.3 ± 770.2
SPAP (mmHg)76.0 ± 43.395.3 ± 31.871.5 ± 44.989.2 ± 38.787.8 ± 42.283.4 ± 33.94.5 ± 20.06.2 ± 26.5−16.4 ± 18.15.8 ± 20.9
TAPSE (cm)1.7 ± 0.41.8 ± 0.31.8 ± 0.41.8 ± 0.31.8 ± 0.41.8 ± 0.3−0.14 ± 0.38−0.01 ± 0.300.05 ± 0.210.06 ± 0.28
LV EI1.33 ± 0.321.42 ± 0.331.28 ± 0.291.44 ± 0.361.34 ± 0.261.28 ± 0.250.05 ± 0.16−0.02 ± 0.49−0.06 ± 0.230.17 ± 0.20
D-dimer (ng/ml)332.9 ± 204.7275.4 ± 240.2218.5 ± 96.0255.8 ± 153.8205.6 ± 108.0301.8 ± 349.7114.4 ± 135.319.7 ± 174.712.9 ± 110.9−46 ± 324.4
PaCO2 (mmHg)91.7 ± 3.694.0 ± 4.591.2 ± 3.394.6 ± 2.992.6 ± 3.192.5 ± 5.0−0.43 ± 1.260.61 ± 5.581.33 ± 3.04−2.14 ± 5.65
Uric acid (umol/l)415.1 ± 93.3427.9 ± 176.6368.8 ± 67.6387.2 ± 92.3398.9 ± 86.4415.9 ± 129.846.4 ± 54.340.8 ± 109.7−30.1 ± 41.3−28.8 ± 90.4

Difference 1, deviation of 1 year and baseline; difference 2, deviation of 1 year and 2 year; 6MWD, 6-minute walk distance. .