Noninvasive Ventilation Weaning in Acute Hypercapnic Respiratory Failure due to COPD Exacerbation: A Real-Life Observational Study
Table 1
Demographics, comorbidities, COPD characteristics, and presence of delirium in study population.
Completed Group ()
Chronic NIV Group ()
Failed Group ()
value
Demographics, (%)
Age (yrs), median (IQR)
79 (74–85)
65 (55–75)
82 (77–84)
<0.01
Males
13 (65)
7 (35)
7 (64)
0.65
BMI (kg/m2), median (IQR)
24.9 (21.1–27.1)
26.2 (24.6–29.1)
23.9 (21–23.4)
0.12
Current or prior smokers
20 (100)
20 (100)
11 (100)
—
Do-not-resuscitate order
2 (10)
1 (5)
5 (45)
0.02
Comorbidities, (%)
Charlson comorbidity index, median (IQR)
6.75 (6-7)
4 (3–5)
7 (6–8)
<0.01
Diabetes mellitus
4 (20)
2 (10)
2 (18)
0.09
Chronic heart diseases
12 (60)
4 (20)
4 (36)
0.09
Prior myocardial infarction
9 (45)
0
4 (36)
0.26
Cerebrovascular diseases
2 (10)
3 (15)
2 (18)
0.51
Chronic liver disease
2 (10)
1 (5)
0
0.25
Solid tumor
2 (10)
1 (5)
2 (18)
0.59
Hematologic malignancy
1 (5)
0
0
0.28
Obstructive sleep apnea syndrome
1 (5)
4 (20)
1 (9)
0.055
Kyphoscoliosis
0
0
2 (18)
0.03
Obesity-hypoventilation syndrome
0
4 (20)
0
0.63
Dementia
0
0
0
—
Psychiatric disorders
2 (10)
9 (45)
3 (27)
0.16
Chronic renal failure
2 (10)
0
2 (18)
0.63
COPD characteristics, (%)
FEV1 (L), median (IQR)
0.79 (0.62–0.99)
0.49 (0.36–0.82)
0.89 (0.69–1)
0.03
FEV1 (%), median (IQR)
42 (35–50)
33 (17–45)
40 (32–49)
0.21
GOLD 4
16 (80)
15 (75)
7 (64)
0.60
Emphysema phenotype
3 (15)
0
5 (45)
0.87
Chronic bronchitis phenotype
15 (75)
9 (45)
4 (36)
0.03
Asthma-COPD overlap phenotype
2 (10)
7 (35)
2 (18)
0.39
Bronchiectasis-COPD overlap phenotype
0
3 (15)
0
0.68
No. of exacerbations in the previous year, median (IQR)
1 (0-1)
3 (2–5)
1 (0–2)
0.07
No. of hospitalizations in the previous year, median (IQR)
1 (0-1)
2 (0–5)
1 (0–2)
0.01
Long-term oxygen therapy
10 (50)
17 (85)
5 (45)
0.81
Prior domiciliary NIV
0
17 (85)
0
0.27
Delirium, (%)
Delirium according to CBM
4 (20)
4 (20)
4 (36)
0.36
Delirium during NIV
4 (20)
4 (20)
3 (27)
0.68
Delirium after NIV discontinuation
0
—
3 (27)
—
BMI, body mass index; CBM, chart-based method; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in the 1st second; GOLD, global initiative for chronic obstructive lung disease; IQR, interquartile range 25th–75th percentile; NIV, noninvasive ventilation. Classification of airflow limitation severity based on postbronchodilator FEV1 [13].
