Prognostic Value of Concomitant Bronchiectasis in Newly Diagnosed Diffuse Panbronchiolitis Patients on a Maintenance Therapy with Macrolides

Table 3

Univariate and multiple Cox regression analyses for predicting the time to exacerbation since beginning of macrolide therapy in newly diagnosed DPB patients.

Parameter	Univariate analysis				Multivariate analysis
	β value	Standard error	OR (95% CI)	value	β value	Standard error	OR (95% CI)	value
Age	0.010	0.006	1.010 (0.999, 1.021)	0.083	—	—	—	—
Female (yes/no)	−0.029	0.189	0.971 (0.670, 1.407)	0.876	—	—	—	—
Smoking (yes/no)	0.350	0.221	1.419 (0.919, 2.190)	0.114	—	—	—	—
Disease duration (year)	0.049	0.023	1.050 (1.004, 1.099)	0.034	—	—	—	—
Chronic sinusitis (yes/no)	0.576	0.333	1.779 (0.927, 3.414)	0.083	—	—	—	—
CHA test (positive/negative)	−0.256	0.263	0.775 (0.462, 1.298)	0.332	—	—	—	—
BMI (kg/m^2)	−0.103	0.024	0.902 (0.861, 0.946)	<0.001	−0.058	0.027	0.943 (0.859, 0.994)	0.028
FEV1 (% pred)	−0.028	0.007	0.972 (0.959, 0.986)	<0.001	−0.016	0.008	0.984 (0.969, 1.000)	0.045
Pseudomonas aeruginosa culture (positive/negative)	0.894	0.197	2.445 (1.660, 3.601)	<0.001	0.444	0.219	1.559 (1.014, 2.359)	0.043
Concomitant bronchiectasis (yes/no)	0.752	0.199	2.121 (1.437, 3.131)	<0.001	0.435	0.214	1.545 (1.016, 2.349)	0.042

BMI: body mass index; CHA: cold hemagglutination; FEV₁: forced expiratory volume in 1 second; OR: odds ratio; CI: confidence interval.