Effect of Tiotropium Bromide on Airway Inflammation and Programmed Cell Death 5 in a Mouse Model of Ovalbumin-Induced Allergic Asthma

Table 1

Characteristics of untreated asthma mice and tiotropium-treated asthma mice.

Characteristics	Untreated asthma mice	Tiotropium-treated asthma mice	value
Pulmonary function
Peak inspiratory flow (L/s)	2.26 ± 0.03	2.29 ± 0.01	0.030
Peak expiratory flow (L/s)	4.66 ± 0.04	4.80 ± 0.12	0.034
Intra-airway pressure (IP, mmHg)	2.38 ± 0.06	2.33 ± 0.06	0.182
Maximum rising slope of IP (mmHg/s)	96.02 ± 3.69	74.90 ± 4.90	<0.001
BALF cytology
Total cell count (×10^4)	35.92 ± 9.05	27.00 ± 3.97	0.064
Macrophages (%)	67.00 ± 4.86	66.50 ± 3.73	0.846
Eosinophils (%)	11.50 ± 3.02	10.50 ± 1.87	0.509
Neutrophils (%)	10.67 ± 2.50	11.5 ± 1.87	0.530
Lymphocytes (%)	10.83 ± 1.47	11.50 ± 2.17	0.549
Pathological scores
Inflammatory cell infiltration	2.50 ± 0.84	1.25 ± 0.42	0.013
Goblet cell hyperplasia	1.92 ± 0.58	1.17 ± 0.41	0.030
Collagen deposition	1.42 ± 0.38	0.67 ± 0.26	0.003

Data are mean ± SD.