Association of Matrix Metalloproteinase 9 (MMP-9) Polymorphisms with Asthma Risk: A Meta-Analysis

Table 3

Results of the pooled and subgroup analyses for the MMP-9 polymorphism and asthma risk.

SNP	Variable		Case/control	Dominant model			Recessive model			Homozygote genotype			Allelic
				OR [95% CI]		I^2 (%)	OR [95% CI]		I^2 (%)	OR [95% CI]		I^2 (%)	OR [95% CI]		I^2 (%)
–1562 C > T	Total	5	899/923	1.17 (0.94, 1.45)	0.158	0	1.14 (0.61, 2.12)	0.688	0	1.18 (0.63, 2.21)	0.602	0	1.14 (0.94, 1.38)	0.168	0
	Adult	3	603/586	1.14 (0.87, 1.48)	0.349	0	1.32 (0.61, 2.87)	0.482	0	1.36 (0.62, 2.97)	0.437	0	1.14 (0.90, 1.44)	0.294	0
	Children	3	296/337	1.23 (0.86, 1.76)	0.268	0	0.85 (0.29, 2.48)	0.766	0	0.90 (0.31, 2.63)	0.845	0	1.16 (0.84, 1.60)	0.369	0
	Caucasian	3	804/740	1.16 (0.93, 1.46)	0.193	0	1.08 (0.56, 2.07)	0.809	0	1.12 (0.59, 2.15)	0.725	0	1.14 (0.93, 1.39)	0.219	0
Gln279Arg	Total	2	745/661	1.09 (0.99, 1.91)	0.065	0	1.20 (0.92, 1.58)	0.183	0	1.26 (0.98, 1.64)	0.073	0	1.11 (1.00, 1.22)	0.044	0
Arg668Gln	Total	2	693/1064	1.65 (1.28, 2.11)	0.000	22.50	2.40 (1.23, 4.72)	0.011	0	2.69 (1.36, 5.33)	0.004	0	1.59 (1.29, 1.97)	0.000	36.90