Postinfectious Bronchiolitis Obliterans in Children: Diagnostic Workup and Therapeutic Options: A Workshop Report

Table 2

Corticosteroids in PIBO.

Study (year) journal	Li et. al. (2014) BMC Pediatrics [64]	Chen et. al. (2012) Chinese Journal of Pediatrics [65]	Wang et. al. (2015) Experimental & Therapeutic Medicine [66]
Number; Comparative design; Study design	42 children; No control group/no placebo; Prospective cohort	26 children; No control group/no placebo; Retrospective cohort	16 children; No control group/no placebo; Retrospective cohort
Treatment regime	Oral prednisone; (1.5 mg/kg/day with weaning for 6–9 mo) and azithromycin (5 mg/kg for 3 d/wk for 6 mo); Some also had i.v. steroids during acute phase	Oral steroid and azithromycin	Oral prednisolone; (1 mg/kg/day with dose reduction of 1.25 mg/month) and azithromycin (7.5 mg/kg twice weekly); Variable treatment duration
Assessment of outcome	Effective (subjective/objective measures PFT <10% decline) or ineffective		Clinical symptoms and HRCT findings
Effectiveness	Effective in 86% at 6 months		10 of 16 improved