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Cardiology Research and Practice
Volume 2009, Article ID 179350, 5 pages
Review Article

Heart Rate and Cardiovascular Disease: An Alternative to Beta Blockers

Department of Cardiology, Waikato Hospital, Pembroke & Selwyn Sts, Private Bag 3200, Hamilton 3240, New Zealand

Received 28 April 2009; Accepted 13 July 2009

Academic Editor: Jalal K. Ghali

Copyright © 2009 Michael Liang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ivabradine, an inhibitor, acts primarily on the sinoatrial node and is used to reduce the heart rate with minimal effect on myocardial contractility, blood pressure, and intracardiac conduction. Heart rate reduction is an important aspect of care in patients with chronic stable angina and heart failure. Many patients with coronary artery disease have coexisting asthma or chronic obstructive airway disease, and most of them are unable to tolerate beta blockers. Ivabradine may thus be a useful medicine in therapeutic heart rate management especially in patients who are intolerant of beta-blockers.