Coronary Artery Disease: A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender

Table 7

The relationship among joint ADA-BW phenotype, gender, and sample (CAD versus newborn).

		CAD		Newborns
		Females	Males	Females	Males
	ADA1/1 BW ≤ 3000 g (A)	42.2%	23.9%	22.3%	18.3%
Joint ADA-BW phenotype	ADA1/1 BW > 3000 g (B)	35.6%	68.7%	62.0%	66.2%
	ADA*2 carrier BW ≤ 3000 g (C)	16.9%	1.5%	3.5%	3.8%
	ADA*2 carrier BW > 3000 g (D)	5.1%	6.0%	12.2%	11.7%
	total no.	59	67	368	394
Three-way contingency table analysis by a log-linear model
x = gender, y = joint ADA-BW phenotype, and z = sample (CAD versus newborns)
x y z interaction     G   df  𝑃
13.605  3  .005
Chi-square test of independence (CAD versus newborns)
χ ^2  df  𝑃
Female/   33.551   3  <10^-6
Males     3.595   3  .308
Odds ratio analysis (CAD versus newborns)
Joint ADA-BW phenotype
A versus others     B versus others    C versus others      D versus others
Females OR         2.564     0.339     5.573      0.384
95% CI      1.392–4.716  0.183–0.623   2.130–14.487   0.099–1.346
Males      OR         1.403         1.116     0.382      0.480
95% CI       0.721–2.701  0.619–2.024     0.016–2.83    0.141–1.457