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Cardiology Research and Practice
Volume 2010, Article ID 542451, 8 pages
http://dx.doi.org/10.4061/2010/542451
Research Article

Adjustment and Characterization of an Original Model of Chronic Ischemic Heart Failure in Pig

1Inserm U 828, Avenue du Haut-Lévêque, 33600 Pessac, France
2Department of Cardiac Surgery and Anesthesiology, Haut-Lévêque Hospital, 33600 Pessac, France
3University of Medicine, Bordeaux 2, rue Léo Saignat, 33000 Bordeaux, France
4Technological Platform for Biomedical Innovation, avenue du Haut-Lévêque, 33600 Pessac, France
5Laboratory of Echocardiography, Haut-Lévêque Hospital, 33600 Pessac, France

Received 11 March 2010; Revised 23 June 2010; Accepted 4 August 2010

Academic Editor: Anne A. Knowlton

Copyright © 2010 Laurent Barandon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We present and characterize an original experimental model to create a chronic ischemic heart failure in pig. Two ameroid constrictors were placed around the LAD and the circumflex artery. Two months after surgery, pigs presented a poor LV function associated with a severe mitral valve insufficiency. Echocardiography analysis showed substantial anomalies in radial and circumferential deformations, both on the anterior and lateral surface of the heart. These anomalies in function were coupled with anomalies of perfusion observed in echocardiography after injection of contrast medium. No demonstration of myocardial infarction was observed with histological analysis. Our findings suggest that we were able to create and to stabilize a chronic ischemic heart failure model in the pig. This model represents a useful tool for the development of new medical or surgical treatment in this field.