Additive Value of B-Type Natriuretic Peptide on Rest ²⁰¹Tl-Dipyridamole Stress ^99mTc-Sestamibi Gated Myocardial SPECT in Patients with Normal Left Ventricular Systolic Function

Table 4

Diagnostic performance of BNP and SPECT for coronary artery disease.

	Sensitivity, %	Specificity, %	PPV, %	NPV, %
Predicting CAD in overall patients ( 𝑛=224)
SPECT (+)	77.7	41.3	66.2	67.1
BNP ≥ 23.0 pg/mL	70.2	56.3	65.4	61.7
Predicting CAD in patients with positive SPECT ( 𝑛=142)
BNP ≥ 23.0 pg/mL	68.1	62.5	78.0	50.0
Predicting CAD in patients with negative SPECT ( 𝑛=82)
BNP ≥ 23.0 pg/mL	70.4	54.5	43.2	78.9
BNP ≥ 23.0 pg/mL	51.9	74.5	50.0	75.9
Predicting CAD in patients with ischemia on LAD territory ( 𝑛=59)
BNP ≥ 23.0 pg/mL	73.7	57.1	75.7	54.5
BNP ≥ 23.0 pg/mL	64.9	59.0	72.7	50.0
Predicting CAD in patients with ischemia on RCA or LCx territory ( 𝑛=83)
BNP ≥ 23.0 pg/mL	71.9	65.4	82.0	51.5
BNP ≥ 23.0 pg/mL	66.6	69.2	82.6	48.6

PPV: positive predictive value; NPV: negative predictive value.