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Cardiology Research and Practice
Volume 2010, Article ID 856418, 9 pages
http://dx.doi.org/10.4061/2010/856418
Research Article

Gadolinium Enhanced MR Coronary Vessel Wall Imaging at 3.0 Tesla

1Department of Medicine/Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
2Division of Magnetic Resonance Research, Department of Radiology, Johns Hopkins University, School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA
3Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205-2196, USA
4Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21205-2196, USA

Received 6 April 2010; Revised 12 July 2010; Accepted 16 September 2010

Academic Editor: Vicky A. Cameron

Copyright © 2010 Sebastian Kelle et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. We evaluated the influence of the time between low-dose gadolinium (Gd) contrast administration and coronary vessel wall enhancement (LGE) detected by 3T magnetic resonance imaging (MRI) in healthy subjects and patients with coronary artery disease (CAD). Materials and Methods. Four healthy subjects (4 men, mean age years and eleven CAD patients (6 women, mean age years) were studied on a commercial 3.0 Tesla (T) whole-body MR imaging system (Achieva 3.0 T; Philips, Best, The Netherlands). T1-weighted inversion-recovery coronary magnetic resonance imaging (MRI) was repeated up to 75 minutes after administration of low-dose Gadolinium (Gd) (0.1 mmol/kg Gd-DTPA). Results. LGE was seen in none of the healthy subjects, however in all of the CAD patients. In CAD patients, fifty-six of 62 (90.3%) segments showed LGE of the coronary artery vessel wall at time-interval 1 after contrast. At time-interval 2, 34 of 42 (81.0%) and at time-interval 3, 29 of 39 evaluable segments (74.4%) were enhanced. Conclusion. In this work, we demonstrate LGE of the coronary artery vessel wall using 3.0 T MRI after a single, low-dose Gd contrast injection in CAD patients but not in healthy subjects. In the majority of the evaluated coronary segments in CAD patients, LGE of the coronary vessel wall was already detectable 30–45 minutes after administration of the contrast agent.