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Cardiology Research and Practice
Volume 2011, Article ID 156326, 8 pages
http://dx.doi.org/10.4061/2011/156326
Review Article

Cardiovascular Complications in CKD Patients: Role of Oxidative Stress

1Nephrology Division, Department of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA
2Lipid Research Laboratory, Emory University School of Medicine, Atlanta, GA 30322, USA
3Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA

Received 14 October 2010; Accepted 8 December 2010

Academic Editor: Ken Ichi Aihara

Copyright © 2011 Elvira O. Gosmanova and Ngoc-Anh Le. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Starting with the early stages, patients with chronic kidney disease (CKD) experience higher burden of cardiovascular disease (CVD). Moreover, CVD complications are the major cause of mortality in CKD patients as compared with complications from chronic kidney failure. While traditional CVD risk factors, including diabetes, hypertension, hyperlipidemia, obesity, physical inactivity, may be more prevalent among CKD patients, these factors seem to underestimate the accelerated cardiovascular disease in the CKD population. Search for additional biomarkers that could explain the enhanced CVD risk in CKD patients has gained increasing importance. Although it is unlikely that any single nontraditional risk factor would fully account for the increased CVD risk in individuals with CKD, oxidative stress appears to play a central role in the development and progression of CVD and its complications. We will review the data that support the contribution of oxidative stress in the pathogenesis of CVD in patients with chronic kidney failure.