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Cardiology Research and Practice
Volume 2011, Article ID 163281, 6 pages
Research Article

The Impact of Demographic Characteristics and Lifestyle in the Distribution of Cystatin C Values in a Healthy Greek Adult Population

1Department of Internal Medicine, Polykliniki General Hospital, 10552 Athens, Greece
2Department of Dietetics and Nutritional Science, Harokopio University of Athens, 17671 Athens, Greece

Received 27 July 2010; Accepted 3 October 2010

Academic Editor: Undurti N. Das

Copyright © 2011 Angelos A. Evangelopoulos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The aim of the present study was to examine sources of variation for serum cystatin C in a healthy Greek population. Methods. Cystatin C together with basic clinical chemistry tests was measured in a total of 490 adults (46±16 yrs, 40% males) who underwent an annual health check. Demographic, anthropometric, and lifestyle characteristics were recorded. Results. Higher values of cystatin C were observed among males (P=.04), participants aged over 65 years (P<.001), current smokers (P=.001) and overweight/obese participants (P=.03). On the contrary, alcohol consumption and physical activity seemed to have no influence on cystatin C levels (P=.61; P=.95, resp.). Conclusions. In interpreting serum cystatin C values in a healthy adult population, age, gender, Body Mass Index, and cigarette smoking need to be considered, and determination of reference ranges among distinct subpopulations seem to be prudent.