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Cardiology Research and Practice
Volume 2011 (2011), Article ID 429487, 8 pages
Research Article

Mediterranean Diet Mediates the Adverse Effect of Depressive Symptomatology on Short-Term Outcome in Elderly Survivors from an Acute Coronary Event

1First Cardiology Clinic, School of Medicine, University of Athens, 46 Paleon Polemiston Street, 166 74 Glyfada, Greece
2Department of Nutrition-Dietetics, Harokopio University, 70 El Venizelou Av., 17671 Athens, Greece

Received 9 September 2010; Accepted 23 February 2011

Academic Editor: Undurti N. Das

Copyright © 2011 Christina Chrysohoou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims. We evaluated the interaction effect between depressive symptoms and dietary habits on 30-day development of cardiovascular disease (CVD) (death or rehospitalization) in elderly, acute coronary syndrome (ACS) survivors. Methods. During 2006–2008, we recorded 277 nonfatal, consecutive ACS admissions (75 ± 6 years, 70% males, 70% had diagnosis of myocardial infarction) with complete 30-day follow-up. Assessment of recent depressive symptoms was based on the CES-D scale. Among sociodemographic, bioclinical, lifestyle characteristics, the MedDietScore that assesses the inherent characteristics of the Mediterranean diet was applied. Results. 22% of the ACS pts developed a CVD event during the first 30 days (14.8% rehospitalization and 9.4% death). Patients in the upper tertile of the CES-D scale (i.e., >18) had higher incidence of CVD events as compared with those in the lowest tertile (21% versus 8%, 𝑃 = . 0 1 ). Multiple logistic regression analysis revealed that 1-unit increase in CES-D was associated with 4% higher odds (95% CI 1.008–1.076, 𝑃 = . 0 1 ) of CVD events; however, when MedDietScore was entered in the model, CES-D lost its significance ( 𝑃 = . 2 0 ). Conclusion. Short-term depressive symptoms are related to a worsen 30-day prognosis of ACS patients; however, this relationship was mediated by Mediterranean diet adherence.