Increased Left Ventricular Stiffness Impairs Exercise Capacity in Patients with Heart Failure Symptoms Despite Normal Left Ventricular Ejection Fraction

<table>Linear regression between peak performance and LV stiffness in all patients (above, <svg height="11.0375" id="M124" style="vertical-align:-0.27588pt" version="1.1" viewbox="0 0 42.912498 11.0375" width="42.912498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.0375)">
<g transform="translate(72,-63.17)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">3</tspan>
<tspan style="font-size: 12.50px; " x="27.969212" y="0">9</tspan>
</text>
</g>
</g>
</svg>) and in HFNEF patients with increased LV stiffness (below, <svg height="10.8125" id="M125" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 42.912498 10.8125" width="42.912498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.8125)">
<g transform="translate(72,-63.35)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="27.969212" y="0">7</tspan>
</text>
</g>
</g>
</svg>). Stiffness beta indicates exponential curve fit to end-diastolic PV relationship, <i>r</i> correlation coefficient, and <i>P</i> significance level.</table>

Cardiology Research and Practice

fig2

Figure 2

Figure 2: Increased Left Ventricular Stiffness Impairs Exercise Capacity in Patients with Heart Failure Symptoms Despite Normal Left Ventricular Ejection Fraction 

Figure 2 | Increased Left Ventricular Stiffness Impairs Exercise Capacity in Patients with Heart Failure Symptoms Despite Normal Left Ventricular Ejection Fraction 