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Cardiology Research and Practice
Volume 2011, Article ID 714515, 10 pages
Review Article

Local Bone Marrow Renin-Angiotensin System and Atherosclerosis

1Department of Gastroenterology, Turkiye Yuksek Ihtisas Teaching and Research Hospital, 06100 Ankara, Turkey
2Department of Gastroenterology, Ankara Numune Education and Research Hospital, 06100 Ankara, Turkey
3Department of Internal Medicine, Faculty of Medicine, Hacettepe University, 06100 Ankara, Turkey

Received 28 September 2010; Revised 14 October 2010; Accepted 23 October 2010

Academic Editor: Masaki Mogi

Copyright © 2011 Yavuz Beyazit et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Local hematopoietic bone marrow (BM) renin-angiotensin system (RAS) affects the growth, production, proliferation differentiation, and function of hematopoietic cells. Angiotensin II (Ang II), the dominant effector peptide of the RAS, regulates cellular growth in a wide variety of tissues in pathobiological states. RAS, especially Ang II and Ang II type 1 receptor (AT1R), has considerable proinflammatory and proatherogenic effects on the vessel wall, causing progression of atherosclerosis. Recent investigations, by analyzing several BM chimeric mice whose BM cells were positive or negative for AT1R, disclosed that AT1R in BM cells participates in the pathogenesis of atherosclerosis. Therefore, AT1R blocking not only in vascular cells but also in the BM could be an important therapeutic approach to prevent atherosclerosis. The aim of this paper is to review the function of local BM RAS in the pathogenesis of atherosclerosis.