Postmyocardial Infarct Remodeling and Heart Failure: Potential Contributions from Pro- and Antiaging Factors

Table 1

Pro- and antiaging factors.

Pro-aging	Antiaging
Reactive O2 (ROS)	Klotho hormone
Hyperperoxides	Melatonin hormone
DNA damage	Sirtuins
Ultraviolet light	WNT
Telomere attrition	Dietary/Calorie Restriction
WNT pathway	Antioxidants
Increased target of rapamycin (TOR) activation	Resveratrol (Sirtuin activator)
Reduced heat shock protein function	Reduced TOR and insulin
Defective lysosomes	Sestrins