Postmyocardial Infarct Remodeling and Heart Failure: Potential Contributions from Pro- and Antiaging Factors

Table 2

Summary of factors in Post-MI remodeling and heart failure.

Parameter of remodeling	Effects on the heart
Changes in Myocytes	Myocyte hypertrophy
	Fetal gene expression
	Increased myocyte length
	Decreased myocyte numbers
	Increased myocyte cell death
Changes in cardiac morphology	Left ventricular dilatation
	Increased extracellular matrix
	Increased spherical shape
	Increased wall thinning
Changes in left ventricular function	Increased oxygen consumption
	Increased adrenergic response
	Increased end systolic and diastolic dysfunction