Preclinical Research into Basic Mechanisms of Radiation-Induced Heart Disease
Table 1
Summary of pre-clinical studies into basic mechanisms of RIHD.
Main Observation or Study Outcome
References
Reduced myocardial capillary density, focal loss of endothelial alkaline phosphatase, and increased expression of von Willebrand factor indicate vascular injury in rat models of RIHD.
Mast cell-deficient rats showed reduced radiation-induced myocardial inflammation and degeneration, but increased myocardial fibrosis when compared to mast cell-competent rats.