Cardiology Research and Practice / 2011 / Article / Tab 6 / Research Article
The Registry and Follow-Up of Complex Pediatric Therapies Program of Western Canada: A Mechanism for Service, Audit, and Research after Life-Saving Therapies for Young Children Table 6 Some specific variables examined for association with outcomes of neonates having complex cardiac surgery for congenital heart disease followed by the Complex Pediatric Therapies Follow-up Program.
Variable examined (years,
𝑛
) Effect on outcomes Postoperative lactate (1996–1999;
𝑛
=
8
5
) [64 ] Associated with mortality; lactate ≥ 7 mmol/L on admission, and d1 peak ≥ 8 mmol/L: sensitivity 83%, specificity 82%. MAP after re-warming in the operating room (1996–1999;
𝑛
=
7
0
) [61 ] Associated with mortality by 5 years of age: minutes MAP ≤ 30 mmHg odds ratio 1.09 (95% CI 1.03, 1.16). Transfusion in Norwood Group (1996–2005;
𝑛
=
8
2
) [62 ] Associated with ventilator days postoperatively: postoperative number of transfusions d2-5 effect size 1.85 (0.33, 3.36) days. Postoperative CPR (1996–2005;
𝑛
=
2
9
) [68 ] Associated with mortality by 2 years (odds ratio 15.02, 95% CI 4.63, 48.76), but not neurodevelopmental outcome in survivors. Perioperative sedation (benzodiazepines, opiates, chloral hydrate, ketamine, inhalational agents; 2003–2006;
𝑛
=
9
5
) [69 ] No evidence of an association with neurodevelopmental outcomes. Deletion 22q11.2 (1996–2004;
𝑛
=
1
6
) [7 ] Associated with MDI and PDI.
MAP: mean arterial pressure: CPR: cardiopulmonary resuscitation; MDI: Mental Developmental Index; PDI: Psychomotor Developmental Index.
