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Cardiology Research and Practice
Volume 2012, Article ID 165957, 8 pages
http://dx.doi.org/10.1155/2012/165957
Research Article

Locally Different Endothelial Nitric Oxide Synthase Protein Levels in Ascending Aortic Aneurysms of Bicuspid and Tricuspid Aortic Valve

1Department of Cardio and Thoracic Vascular Surgery, University Clinic of Schleswig-Holstein (UKSH), Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
2Center for Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany

Received 27 January 2012; Revised 26 March 2012; Accepted 28 March 2012

Academic Editor: Adrian H. Chester

Copyright © 2012 Salah A. Mohamed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. C. Siu and C. K. Silversides, “Bicuspid aortic valve disease,” Journal of the American College of Cardiology, vol. 55, no. 25, pp. 2789–2800, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Bonderman, E. Gharehbaghi-Schnell, G. Wollenek, G. Maurer, H. Baumgartner, and I. M. Lang, “Mechanisms underlying aortic dilatation in congenital aortic valve malformation,” Circulation, vol. 99, no. 16, pp. 2138–2143, 1999. View at Google Scholar · View at Scopus
  3. M. Nataatmadja, M. West, J. West et al., “Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in Marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm,” Circulation, vol. 108, supplement 1, pp. II329–II334, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. T. C. Lee, Y. D. Zhao, D. W. Courtman, and D. J. Stewart, “Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase,” Circulation, vol. 101, no. 20, pp. 2345–2348, 2000. View at Google Scholar · View at Scopus
  5. P. J. Kuhlencordt, R. Gyurko, F. Han et al., “Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice,” Circulation, vol. 104, no. 4, pp. 448–454, 2001. View at Google Scholar · View at Scopus
  6. D. Aicher, C. Urbich, A. Zeiher, S. Dimmeler, and H. J. Schafers, “Endothelial nitric oxide synthase in bicuspid aortic valve disease,” Annals of Thoracic Surgery, vol. 83, no. 4, pp. 1290–1294, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. V. Ranjan, Z. Xiao, and S. L. Diamond, “Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress,” American Journal of Physiology, vol. 269, no. 2, pp. H550–H555, 1995. View at Google Scholar · View at Scopus
  8. Y. C. Boo and H. Jo, “Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases,” American Journal of Physiology, vol. 285, no. 3, pp. C499–C508, 2003. View at Google Scholar · View at Scopus
  9. E. Weigang, F. A. Kari, F. Beyersdorf et al., “Flow-sensitive four-dimensional magnetic resonance imaging: flow patterns in ascending aortic aneurysms,” European Journal of Cardio-thoracic Surgery, vol. 34, no. 1, pp. 11–16, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. A. J. Barker, C. Lanning, and R. Shandas, “Quantification of hemodynamic wall shear stress in patients with bicuspid aortic valve using phase-contrast MRI,” Annals of Biomedical Engineering, vol. 38, no. 3, pp. 788–800, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. S. A. Mohamed, M. Misfeld, T. Hanke et al., “Inhibition of caspase-3 differentially affects vascular smooth muscle cell apoptosis in the concave versus convex aortic sites in ascending aneurysms with a bicuspid aortic valve,” Annals of Anatomy, vol. 192, no. 3, pp. 145–150, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. S. A. Mohamed and H. H. Sievers, “Ascending aneurysms in bicuspid aortic valve,” in Diagnosis and Treatment of Abdominal and Thoracic Aortic Aneurysms Including the Ascending Aorta and the Aortic Arch, R. T. Grundmann, Ed., pp. 161–174, InTech, Rijeka, Croatia, 2011. View at Google Scholar
  13. J. Li, T. R. Billiar, R. V. Talanian, and Y. M. Kim, “Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation,” Biochemical and Biophysical Research Communications, vol. 240, no. 2, pp. 419–424, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. B. Kazmierczak, S. Bartnitzke, M. Hartl, and J. Bullerdiek, “In vitro transformation by the SV40 “early region” of cells from a human benign salivary gland tumor with a 12q13→p15 rearrangement,” Cytogenetics and Cell Genetics, vol. 53, no. 1, pp. 37–39, 1990. View at Google Scholar · View at Scopus
  15. G. Belge, B. Kazmierczak, K. Meyer-Bolte, S. Bartnitzke, and J. Bullerdiek, “Expression of SV40 T-antigen in lipoma cells with a chromosomal translocation t(3;12) is not sufficient for direct immortalization,” Cell Biology International Reports, vol. 16, no. 4, pp. 339–347, 1992. View at Google Scholar · View at Scopus
  16. G. van Loo, M. van Gurp, B. Depuydt et al., “The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity,” Cell Death and Differentiation, vol. 9, no. 1, pp. 20–26, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. Q. L. Deveraux and J. C. Reed, “IAP family proteins—suppressors of apoptosis,” Genes & Development, vol. 13, no. 3, pp. 239–252, 1999. View at Google Scholar · View at Scopus
  18. W. C. Sessa, “eNos at a glance,” Journal of Cell Science, vol. 117, no. 12, pp. 2427–2429, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. D. M. Dudzinski, J. Igarashi, D. Greif, and T. Michel, “The regulation and pharmacology of endothelial nitric oxide synthase,” Annual Review of Pharmacology and Toxicology, vol. 46, pp. 235–276, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. M. T. Gewaltig and G. Kojda, “Vasoprotection by nitric oxide: mechanisms and therapeutic potential,” Cardiovascular Research, vol. 55, no. 2, pp. 250–260, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. P. L. Huang, “eNOS, metabolic syndrome and cardiovascular disease,” Trends in Endocrinology & Metabolism, vol. 20, no. 6, pp. 295–302, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. F. X. Schmid, K. Bielenberg, A. Schneider, A. Haussler, A. Keyser, and D. Birnbaum, “Ascending aortic aneurysm associated with bicuspid and tricuspid aortic valve: involvement and clinical relevance of smooth muscle cell apoptosis and expression of cell death-initiating proteins,” European Journal of Cardio-thoracic Surgery, vol. 23, no. 4, pp. 537–543, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. M. E. Ward, M. Toporsian, J. A. Scott et al., “Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant,” Journal of Clinical Investigation, vol. 115, no. 11, pp. 3128–3139, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. I. B. Buchwalow, T. Podzuweit, V. E. Samoilova et al., “An in situ evidence for autocrine function of NO in the vasculature,” Nitric Oxide, vol. 10, no. 4, pp. 203–212, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. I. B. Buchwalow, S. Cacanyiova, J. Neumann, V. E. Samoilova, W. Boecker, and F. Kristek, “The role of arterial smooth muscle in vasorelaxation,” Biochemical and Biophysical Research Communications, vol. 377, no. 2, pp. 504–507, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. M. S. Bhuiyan and K. Fukunaga, “Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury,” Cardiovascular Therapeutics, vol. 26, no. 3, pp. 224–232, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. J. E. Chipuk and D. R. Green, “Do inducers of apoptosis trigger caspase-independent cell death?” Nature Reviews Molecular Cell Biology, vol. 6, no. 3, pp. 268–275, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. S. A. Mohamed, T. Hanke, A. W. Erasmi et al., “Mitochondrial DNA deletions and the aging heart,” Experimental Gerontology, vol. 41, no. 5, pp. 508–517, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. P. S. Brookes, E. P. Salinas, K. Darley-Usmar et al., “Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release,” Journal of Biological Chemistry, vol. 275, no. 27, pp. 20474–20479, 2000. View at Publisher · View at Google Scholar · View at Scopus
  30. H. M. Razavi, J. A. Hamilton, and Q. Feng, “Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure,” Pharmacology and Therapeutics, vol. 106, no. 2, pp. 147–162, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. Q. B. Liu, L. L. Liu, Y. M. Lu et al., “The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells,” Toxicology and Applied Pharmacology, vol. 244, no. 3, pp. 374–384, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. W. C. Roberts, “The congenitally bicuspid aortic valve. A study of 85 autopsy cases,” The American Journal of Cardiology, vol. 26, no. 1, pp. 72–83, 1970. View at Google Scholar · View at Scopus
  33. H. H. Sievers and C. Schmidtke, “A classification system for the bicuspid aortic valve from 304 surgical specimens,” Journal of Thoracic and Cardiovascular Surgery, vol. 133, no. 5, pp. 1226–1233, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. B. M. Schaefer, M. B. Lewin, K. K. Stout et al., “The bicuspid aortic valve: an integrated phenotypic classification of leaflet morphology and aortic root shape,” Heart, vol. 94, no. 12, pp. 1634–1638, 2008. View at Publisher · View at Google Scholar · View at Scopus