Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease
Figure 1
Association between plasma ADMA levels (μmol/L) and acute myocardial infarction in subsets of the study population with low/high serum levels of α-linolenic acid (upper panels) or total fatty acids (lower panels). Median serum levels of the specified fatty acid were used for the dichotomous separation of the study subjects. The nonlinear smoothing splines estimate of the hazard ratio were estimated with additive Cox proportional hazard regression models adjusted for age (continuous), sex, diabetes mellitus (yes/no), current smoking (yes/no), acute coronary syndrome (yes/no), extend of coronary artery disease (0–3), and left ventricular ejection fraction (continuous). The solid line represents the hazard ratio, and the shaded area represents the 95% CI. The density plot on top of the -axis shows the distribution of plasma ADMA in the study population and the white vertical lines denote the first quartile, median, and third quartile, respectively; the dotted vertical line marks the population 90th percentile.
