Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease

Table 3

Risk of acute myocardial infarction across quartiles and upper decile of ADMA.

Model	Quartiles							Upper decile
		2		3		4	𝑃 trend
	HR	95% CI	HR	95% CI	HR	95% CI		HR	95% CI	𝑃 value
Univariate	1.26	(0.75, 2.12)	1.23	(0.73, 2.07)	1.47	(0.89, 2.42)	0.16	2.24	(1.45, 3.47)	<0.001
Sex, age adjusted	1.22	(0.72, 2.07)	1.16	(0.69, 1.96)	1.35	(0.80, 2.25)	0.32	2.06	(1.33, 3.21)	0.001
Multivariate adjusted^1	1.22	(0.72, 2.07)	1.27	(0.74, 2.18)	1.44	(0.84, 2.47)	0.20	2.11	(1.34, 3.32)	0.001

HR: hazard ratio; CI: confidence interval.
Hazard ratios for the quartile groups are compared to first quartile; hazard ratio for plasma ADMA levels > 90th percentile is compared to plasma ADMA levels < 90th percentile.
¹The model includes age (continuous), sex, acute coronary syndrome (yes/no), diabetes mellitus (yes/no), hypertension (yes/no), current smoking (yes/no), extend of coronary artery disease (0–3), and left ventricular ejection fraction (continuous).